Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UIC Tests Two Drugs for Pediatric Bipolar Disorder

19.10.2004


University of Illinois at Chicago researchers are comparing two drugs used to treat pediatric bipolar disorder patients to evaluate how the drugs affect brain function in children with the disorder.

"More and more clinicians are using second generation anti-psychotics to treat children with bipolar disorder, but there are no randomized controlled trials of these medications," said Dr. Mani Pavuluri, director of the Pediatric Mood Disorders Clinic at UIC and principal investigator of the study. The study is innovative because it was designed so that all kids receive active, yet double-blinded, treatment and brain function testing, Pavuluri said.

Bipolar disorder, also known as manic-depression, is characterized by extreme changes in mood. Patients may alternate between deep depression and abnormal and persistent euphoria, or mania. In children, the disorder is associated with sexual promiscuity, failure in school, and suicide. It is often misdiagnosed and treated unsuccessfully.



In the first phase of the study, researchers will enroll about 30 children between the ages of 5 and 18 with bipolar disorder. During the six-week clinical trial, children will be randomly assigned to receive either risperidone (a novel antipsychotic) or divalproex sodium (a standard mood stabilizer).

Researchers will closely monitor the patient’s physical and mental health during the study. The child, the child’s parents and teacher will be asked to complete questionnaires regarding how the child thinks and behaves while participating in the study. In the second phase of the study, a subset of children between the ages of 12 and 18 who are enrolled in the drug trial will be evaluated using functional magnetic resonance imaging, known as fMRI.

The non-invasive procedure allows researchers to map brain activity when patients perform specific tasks or are exposed to specific stimuli. The functional MRI testing will take place before and after receiving medication. Fifteen healthy children of comparable age and sex will be recruited to complete the functional MRI studies and serve as a control group for the study. "This trial not only looks at drug efficacy using paper and pencil measures, but includes fMRI to look at pre- and post-blood flow alterations in the brain indicating functional changes," said Pavuluri.

Existing treatment strategies for pediatric bipolar disorder are often inadequate and not well tolerated, according to Pavuluri. The study aims to identify whether a novel antipsychotic will offer a more favorable response with fewer side effects than a standard mood stabilizer.

The National Institutes of Health is funding the study. For more information about the clinical trial, call (312) 413-1710. For more information about the Pediatric Mood Disorders Clinic, visit www.psych.uic.edu/pmdc

Sherri McGinnis González | EurekAlert!
Further information:
http://www.psych.uic.edu/pmdc
http://www.uic.edu

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Fraunhofer ISE Pushes World Record for Multicrystalline Silicon Solar Cells to 22.3 Percent

25.09.2017 | Power and Electrical Engineering

Usher syndrome: Gene therapy restores hearing and balance

25.09.2017 | Health and Medicine

An international team of physicists a coherent amplification effect in laser excited dielectrics

25.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>