Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UIC Tests Two Drugs for Pediatric Bipolar Disorder

19.10.2004


University of Illinois at Chicago researchers are comparing two drugs used to treat pediatric bipolar disorder patients to evaluate how the drugs affect brain function in children with the disorder.

"More and more clinicians are using second generation anti-psychotics to treat children with bipolar disorder, but there are no randomized controlled trials of these medications," said Dr. Mani Pavuluri, director of the Pediatric Mood Disorders Clinic at UIC and principal investigator of the study. The study is innovative because it was designed so that all kids receive active, yet double-blinded, treatment and brain function testing, Pavuluri said.

Bipolar disorder, also known as manic-depression, is characterized by extreme changes in mood. Patients may alternate between deep depression and abnormal and persistent euphoria, or mania. In children, the disorder is associated with sexual promiscuity, failure in school, and suicide. It is often misdiagnosed and treated unsuccessfully.



In the first phase of the study, researchers will enroll about 30 children between the ages of 5 and 18 with bipolar disorder. During the six-week clinical trial, children will be randomly assigned to receive either risperidone (a novel antipsychotic) or divalproex sodium (a standard mood stabilizer).

Researchers will closely monitor the patient’s physical and mental health during the study. The child, the child’s parents and teacher will be asked to complete questionnaires regarding how the child thinks and behaves while participating in the study. In the second phase of the study, a subset of children between the ages of 12 and 18 who are enrolled in the drug trial will be evaluated using functional magnetic resonance imaging, known as fMRI.

The non-invasive procedure allows researchers to map brain activity when patients perform specific tasks or are exposed to specific stimuli. The functional MRI testing will take place before and after receiving medication. Fifteen healthy children of comparable age and sex will be recruited to complete the functional MRI studies and serve as a control group for the study. "This trial not only looks at drug efficacy using paper and pencil measures, but includes fMRI to look at pre- and post-blood flow alterations in the brain indicating functional changes," said Pavuluri.

Existing treatment strategies for pediatric bipolar disorder are often inadequate and not well tolerated, according to Pavuluri. The study aims to identify whether a novel antipsychotic will offer a more favorable response with fewer side effects than a standard mood stabilizer.

The National Institutes of Health is funding the study. For more information about the clinical trial, call (312) 413-1710. For more information about the Pediatric Mood Disorders Clinic, visit www.psych.uic.edu/pmdc

Sherri McGinnis González | EurekAlert!
Further information:
http://www.psych.uic.edu/pmdc
http://www.uic.edu

More articles from Studies and Analyses:

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Previous evidence of water on mars now identified as grainflows

21.11.2017 | Physics and Astronomy

NASA's James Webb Space Telescope completes final cryogenic testing

21.11.2017 | Physics and Astronomy

New catalyst controls activation of a carbon-hydrogen bond

21.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>