Dartmouth Medical School cardiology researchers have discovered a new mechanism for what drives the growth of muscle tissue in the lining of injured heart vessels that can eventually lead to blockage. Their study, reported in the October 19 issue of the journal Circulation, raises important questions about the use of drugs that promote or prevent angiogenesis - the formation of blood vessels - to treat the condition.
Normal heart arteries have a muscle tissue layer inside their walls. In coronary artery disease or in response to mechanical injury such as angioplasty (a non-surgical procedure to open clogged arteries), new smooth muscle cells grow along the innermost layer of the arterial lining and leads to narrowing. Such muscle buildup also occurs with use of a stent – a small wire mesh tube inserted after angioplasty to keep the artery clear.
It is the most common cause of stent failure, according to Michael Simons, professor of medicine and of pharmacology and toxicology at Dartmouth Medical School and chief of cardiology at Dartmouth-Hitchcock Medical Center, who headed the research team. Based on the research, Simons cautions against using angiogenic drugs to unblock arteries in certain heart conditions. He indicated that stents coated with agents that specifically target smooth muscle to prevent or kill growth should remain the treatment of choice at present. "They are not perfect, so everyone is looking for what can be added to make things better," he noted.
Andrew Nordhoff | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology