Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Type of hormone therapy may affect heart attack severity

11.10.2004


Research in monkeys suggests that the type of progestin in hormone therapy could dramatically affect heart attack severity. The study, by a Wake Forest University Baptist Medical Center researcher and colleagues, was reported today at the annual meeting of the North American Menopause Society in Washington, D.C.



"One type of hormone therapy limited heart muscle damage to only 5 percent while another resulted in permanent damage to 35 percent of muscle," said J. Koudy Williams, Ph.D., lead investigator, from Wake Forest Baptist. "If we can learn more about this mechanism we might be able to identify better hormone therapies for postmenopausal women."

For years, hormone therapy was prescribed as a way to prevent heart vessel disease in women. But then several research studies, including the Women’s Health Initiative, showed that combination therapy (estrogen plus progestin) increased the risk of both a first and second heart attack in older women. "These studies didn’t look at the amount of heart damage that occurs if a postmenopausal woman has a heart attack," said Williams. "This is important to know because even though the drugs are no longer recommended to prevent heart disease, many women take them for menopausal symptoms or to protect their bones."


In a study of postmenopausal monkeys, Williams and colleagues compared the protestin in Prempro®, the most widely prescribed hormone therapy, with the progestin in Femhrt®. One group of monkeys got estrogen and the Femhrt progestin, one got estrogen and the Prempro progestin and one group didn’t get hormone therapy. The monkey took the drugs for one year in doses equivalent to those prescribed to women.

The researchers then measured the amount of irreversible muscle damage that resulted after an experimentally produced heart attack. The Femhrt group had 5 percent muscle damage, the group that didn’t take hormone therapy had 20 percent damage, and the Prempro group had 35 percent damage. "We were very surprised," said Williams. "The two progestins produced dramatically different results."

The amount of heart muscle damage can affect risk of a future heart attack and risk of developing heart failure, the inability of the heart to meet the body’s demands. Williams said the results suggest that all hormone therapy drugs are not the same and that there may be better treatments than current formulations. He said, however, that the results are too preliminary to apply to women.

Next, the researchers want to learn how estrogen alone – without a progestin – will affect the amount of muscle damage. They also want to learn more about what caused the differences in muscle damage. They suspect that it is related to the amount of inflammation that occurs after a heart attack. They measured an enzyme that is a marker of whether white blood cells, which fight infection, are interacting with heart muscle cells. The Femhrt group had the lowest levels of the enzyme. "We want to learn more about the inflammation pathway," said Williams. "By learning what treatments cause inflammation, we hope we can identify treatments to reduce it." The group, for example, wants to see how soy, which has anti-inflammatory properties, would affect muscle damage.

Progestin is a synthetic progesterone hormone. Progesterone is a female sex hormone essential for the healthy functioning of the reproductive system. In hormone therapy, progestin is used in combination with estrogen to reduce the risk of cancer of the uterus that occurs when estrogen is taken alone.

The progestin in Femhrt is norethindrone acetate. The progestin in Prempro is medroxyprogesterone acetate. Both groups of monkeys taking estrogen got the same type – ethinyl estradiol.

Other researchers were Irma Suparto, M.D., from the Institute Pertanian Bogor in Indonesia and Jacob Vinten-Johansen, Ph.D., a professor or surgery at Emory University.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>