Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Intensity modulated radiation therapy reduces radiation dose to healthy breast tissue

06.10.2004


Results from a University of Pittsburgh study evaluating intensity modulated radiation therapy (IMRT) for breast cancer indicate that IMRT results in a lower dose of radiation to healthy breast tissue when compared to standard radiation. The findings were presented today at the 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Atlanta.



"More than 70 percent of breast cancer patients receive ionizing radiation therapy to treat their disease," said Dwight E. Heron, M.D., study co-author and assistant professor of radiation oncology, University of Pittsburgh School of Medicine and vice chairman of radiation oncology, University of Pittsburgh Medical Center. "While these high-energy beams are targeted to the tumor site as precisely as possible, they often inadvertently injure healthy breast tissue that surrounds the tumor site, limiting the doses of radiation that can be used to effectively destroy cancer cells. With this study, we sought to discover whether tightly focused radiation beams, such as those provided by IMRT, would make a difference in the amount of radiation received by the side of the breast opposite from the tumor site."

In the study, 65 patients with breast cancer who had received breast-conserving surgery were treated with IMRT using the Eclipseâ Planning System, Varian Medical Systems, and compared with 18 patients treated with conventional 2D or 3D radiation therapy. Results indicated a 35 percent reduction in radiation dose to the breast opposite the tumor site at the 4 cm position from the patient’s midline and a 57 percent reduction at the 8 cm position in favor of those patients treated with IMRT.


"These results are encouraging evidence that breast cancer patients can benefit from IMRT," said Dr. Heron. "With more homogenous and conformal treatment, breast cancer patients may be spared side effects from standard radiotherapy that can include skin irritation and breakdown and scarring of the lungs. The risk of treatment-related heart complications, though rare, also may be further reduced with IMRT."

During radiation therapy, high-energy beams are aimed at cancer cells to destroy them by permanently damaging their underlying genetic material. Unlike standard radiation therapy, IMRT administers a radiation field that consists of several hundred small beams of varying intensities that pass through normal tissue without doing significant damage, but converge to give a precise dose of radiation at the tumor site. IMRT can potentially limit the adverse side effects from radiation while increasing the intensity of doses that can be given to effectively destroy cancer cells.

IMRT is combined with a process called inverse treatment planning to determine the best way to treat a patient. It relies on CT (computed tomography) data from patients that is processed and analyzed by a complex computer system to produce the ideal radiation dose distribution for that patient.

Co-authors of the study include Deborah Sonnick, C.M.D.; Ajay Bhatnagar, M.D.; Edward Brandner, Ph.D.; Kristina Gerszten, M.D.; and Melvin Deutsch, M.D.; all with the department of radiation oncology at the University of Pittsburgh School of Medicine.

Clare Collins | EurekAlert!
Further information:
http://www.upmc.edu

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

IHP presents the fastest silicon-based transistor in the world

05.12.2016 | Power and Electrical Engineering

InLight study: insights into chemical processes using light

05.12.2016 | Materials Sciences

High-precision magnetic field sensing

05.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>