Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds chemotherapy helps women with localized ovarian cancer

27.09.2004


A new study finds chemotherapy improves survival and reduces the risk of recurrence in women with stage I ovarian cancer (cancer that has not spread beyond the ovary). But it remains unclear which patients would most benefit from adjuvant chemotherapy and what the optimal treatment regimen would entail. The findings come from an analytical review of data from 13 randomized control trials (RCTs), which will be published in the November 1, 2004 issue of CANCER, a peer-reviewed journal of the American Cancer Society. A free abstract of this article will be available via the CANCER News Room upon online publication.

About one quarter of all ovarian cancers are caught while confined to the ovaries, when five-year survival is 85 percent. But the therapeutic benefit of adjuvant chemotherapy remains controversial. All physicians agree that surgery that includes staging is critical to survival. Some doctors may prefer not to offer chemotherapy for their patients, since eight in ten are adequately treated by surgery alone. They could argue that giving all stage I patients chemotherapy would lead to unnecessary adverse events with no survival benefit for the majority of patients.

Given the controversy, Laurie Elit, M.D., of the Juravinski Regional Cancer Centre in Ontario, Canada and her colleagues conducted a meta-analysis of RCT data published since 1965.



First, adequate surgical staging was a prognostic factor for cancer survival. Most studies in this review did not show adequate staging of patients. Second, patients who received any adjuvant chemotherapy had a lower risk of death (relative risk, 0.74) and recurrence (relative risk, 0.70) than those who did not receive chemotherapy. However, insufficient data and conflicting data exist regarding the optimal regimens (e.g., three versus six cycles), optimal doses, and the role of adjuvant radiotherapy.

The authors strongly recommend that women receive appropriate surgical staging: "women with optimally staged stage I ovarian cancer, a pathology review by a gynecologic pathologist, and good prognostic factors (stage Ia or stage Ib grade 1) have an excellent prognosis without adjuvant chemotherapy." They add: "There is evidence adjuvant chemotherapy improves survival and decreases recurrence rates. What remains to be defined is the population of stage I patients who would most benefit from adjuvant therapy, the optimal chemotherapy regimen, and the dose and duration of treatment."

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/cancer-newsroom
http://www.wiley.com

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>