Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Blood test may be superior to Ct scans in predicting survival in some ovarian cancer patients


Test may allow patients to avoid costly and time-consuming CT scans

A new study shows that the CA125 blood test, which measures the level of protein produced by ovarian cancer cells in the blood, may be superior to standard imaging techniques like CT scans in predicting survival in patients with recurrent ovarian cancer. The study, to be published online September 13 in the Journal of Clinical Oncology, is the first to compare the two procedures with respect to survival.

"This is good news for patients – our study indicates that selected patients can be safely monitored by blood tests alone and thus avoid costly and time consuming CT scans," said Bo Gronlund, MD, lead author and head of the CODOVA database at the Department of Oncology at Rigshospitalet, the Copenhagen University Hospital.

CT scans and other imaging techniques are often used in patients with recurrent cancer to assess whether the patient is responding to treatment. RECIST, the standard criteria for analyzing CT scans and ultrasonography, assesses treatment response by measuring the growth or shrinkage of the tumor.

However, unlike other solid tumors, ovarian cancer spreads diffusely through the abdomen, making tumor tissue much more difficult to detect through CT scans. As a result, response cannot always be measured by RECIST criteria.

Researchers hypothesized that the CA125 blood test might be a better tool for observing tumor growth among patients whose cancer has returned than traditional imaging techniques. To compare the two procedures, they used the RECIST criteria and a set of criteria for the CA125 blood test, which assesses treatment response according to the level of CA125 protein present in the blood.

Using one of the world’s largest database of patients with recurrent ovarian cancer, researchers retrospectively studied 131 patients receiving topotecan or paclitaxel-carboplatin as a second-line chemotherapy. Researchers found that the CA125 criteria were 2.6 times more accurate than RECIST in predicting survival, and concluded that in selected patients, tumor-marker guided response criteria like CA125 may be superior to imaging-based response criteria in predicting the outcome of second-line chemotherapy.

However, researchers noted that the study findings are only applicable to patients treated with topecan or paclitaxel-carboplatin, and pointed to the need for a randomized trial that includes additional chemotherapy agents or novel targeted therapies and that assesses CA125 and RECIST criteria in predicting both survival and quality of life.

An accompanying editorial by Professor Gordon J.S. Rustin of Mount Vernon Cancer Centre in Middlesex, UK underscored the importance of determining which response criteria is the more reliable method for predicting survival and clinical benefit.

"The CA125 response criteria has great potential value in clinical trials. Increased confidence in a CA125 response definition should lead to a cheaper, and in some cases, more accurate method for monitoring ovarian cancer therapy than standard radiographic criteria," he said.

Carrie Housman | EurekAlert!
Further information:

More articles from Studies and Analyses:

nachricht Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung

nachricht High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Greater Range and Longer Lifetime

26.10.2016 | Power and Electrical Engineering

VDI presents International Bionic Award of the Schauenburg Foundation

26.10.2016 | Awards Funding

3-D-printed magnets

26.10.2016 | Power and Electrical Engineering

More VideoLinks >>>