Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Blood test may be superior to Ct scans in predicting survival in some ovarian cancer patients

13.09.2004


Test may allow patients to avoid costly and time-consuming CT scans



A new study shows that the CA125 blood test, which measures the level of protein produced by ovarian cancer cells in the blood, may be superior to standard imaging techniques like CT scans in predicting survival in patients with recurrent ovarian cancer. The study, to be published online September 13 in the Journal of Clinical Oncology, is the first to compare the two procedures with respect to survival.

"This is good news for patients – our study indicates that selected patients can be safely monitored by blood tests alone and thus avoid costly and time consuming CT scans," said Bo Gronlund, MD, lead author and head of the CODOVA database at the Department of Oncology at Rigshospitalet, the Copenhagen University Hospital.


CT scans and other imaging techniques are often used in patients with recurrent cancer to assess whether the patient is responding to treatment. RECIST, the standard criteria for analyzing CT scans and ultrasonography, assesses treatment response by measuring the growth or shrinkage of the tumor.

However, unlike other solid tumors, ovarian cancer spreads diffusely through the abdomen, making tumor tissue much more difficult to detect through CT scans. As a result, response cannot always be measured by RECIST criteria.

Researchers hypothesized that the CA125 blood test might be a better tool for observing tumor growth among patients whose cancer has returned than traditional imaging techniques. To compare the two procedures, they used the RECIST criteria and a set of criteria for the CA125 blood test, which assesses treatment response according to the level of CA125 protein present in the blood.

Using one of the world’s largest database of patients with recurrent ovarian cancer, researchers retrospectively studied 131 patients receiving topotecan or paclitaxel-carboplatin as a second-line chemotherapy. Researchers found that the CA125 criteria were 2.6 times more accurate than RECIST in predicting survival, and concluded that in selected patients, tumor-marker guided response criteria like CA125 may be superior to imaging-based response criteria in predicting the outcome of second-line chemotherapy.

However, researchers noted that the study findings are only applicable to patients treated with topecan or paclitaxel-carboplatin, and pointed to the need for a randomized trial that includes additional chemotherapy agents or novel targeted therapies and that assesses CA125 and RECIST criteria in predicting both survival and quality of life.

An accompanying editorial by Professor Gordon J.S. Rustin of Mount Vernon Cancer Centre in Middlesex, UK underscored the importance of determining which response criteria is the more reliable method for predicting survival and clinical benefit.

"The CA125 response criteria has great potential value in clinical trials. Increased confidence in a CA125 response definition should lead to a cheaper, and in some cases, more accurate method for monitoring ovarian cancer therapy than standard radiographic criteria," he said.

Carrie Housman | EurekAlert!
Further information:
http://www.asco.org

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>