Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer drug may reduce kidney disease in lupus

08.09.2004


A drug that is already being tested as an anticancer agent, especially in lymphoma, may also reduce the kidney disease that is a result of systemic lupus, according to a researcher at Wake Forest University Baptist Medical Center.



The drug, SAHA (suberoylanilide hydroxamic acid ), inhibited the onset of lupus-related kidney disease in mice with lupus, said Nilamadhab Mishra, M.D., an assistant professor of internal medicine - rheumatology, writing in the Sept. 15 issue of The Journal of Immunology, published online today.

Systemic lupus affects an estimated 1.5 million Americans, mostly women, and about half have kidney damage. In systemic lupus, the normally protective immune system attacks the body’s own organs, damaging kidneys, heart, lungs, brain, blood or skin. Most people with lupus have achy or swollen joints, frequent fevers and prolonged or extreme fatigue.


Besides preventing kidney disease, SAHA decreased the size of the spleen in the mice and at the same time decreased the production of certain T-cells (a type of white blood cell) that are a key to the autoimmune disorder, when compared to mice with lupus that didn’t get the drug. It also decreased excess protein in the urine in the mice.

"Further studies are needed to delineate the most effective therapeutic regimen," Mishra and seven colleagues reported in the article. They also need to determine "the precise mechanisms of the anti-inflammatory properties of SAHA in lupus."

The mice in the study have a defective gene and spontaneously develop lupus, including lymph node swelling and increased spleen size, said Mishra.

The researchers reported that SAHA caused no adverse effects in the animals at the doses given.

Mishra said he hoped to start a phase I clinical trial of SAHA in lupus patients next year. Phase I studies are primarily concerned with assessing a drug’s safety.

Mishra said it would be a double blind study, in which neither doctor nor patient will know whether they received SAHA or an inert placebo until the end of the study.

The compound is the second that Mishra and his colleagues have tested in mice that may lead to new treatment of systemic lupus. In February 2003 they reported in the Journal of Clinical Investigation that trichostatin A, or TSA, reduced excess protein in urine, inflammation of the kidneys and spleen weight.

Mishra’s colleagues in the study included Christopher M. Reilly, Ph.D., from Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech in Blacksburg, Va., Gary S. Gilkeson M.D., of the Medical University of South Carolina in Charleston, and scientists at the University of Miami Medical Center in Miami and Memorial Sloan-Kettering Cancer Center in New York. Reilly and Gilkerson were involved in the TSA research as well.

Robert Conn | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Studies and Analyses:

nachricht Do microplastics harbour additional risks by colonization with harmful bacteria?
05.04.2018 | Leibniz-Institut für Ostseeforschung Warnemünde

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>