Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Long-term outcomes for liver transplantation due to hepatitis C

08.09.2004


A new study on liver transplants necessitated by the hepatitis C virus (the most common indication for this type of transplant) found that long-term outcomes are similar to patients receiving transplants due to other diseases. It was the first study to examine long-term transplantation results in hepatitis C patients and to identify risk factors that might lead to transplant failure or death.



The results of this study appear in the September 2004 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). The journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/livertransplantation.

Unlike other liver diseases, hepatitis C infection commonly recurs in transplant patients. Although previous studies had shown that short-term transplantation survival rates for hepatitis C patients were similar to patients undergoing transplants for other indications, a recent analysis of the United Network for Organ Sharing (UNOS) database suggested that five-year transplant outcomes may be poorer for hepatitis C patients. The current study utilized the Liver Transplantation Database, which was established in 1990 by the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) to collect data on patients being evaluated for liver transplants.


Led by Michael Charlton, M.D. of the division of Gastroenterology & Hepatology at the Mayo Clinic in Rochester MN, researchers examined the records of 165 patients with hepatitis C who underwent liver transplants and were followed for up to 12 years post transplant. They found that these patients had 10-year outcomes similar to patients undergoing liver transplants for other reasons, that the most common cause of death or transplant failure in these patients was due to recurrence of hepatitis C, and that risk of transplant failure increased over time.

In addition, researchers examined a number of factors to see if they could be used to predict transplant success. These included recipient age, donor age, bilirubin, INR (a measure of blood-clotting capability), and viral load and the presence of cytomegalovirus (CMV) antibodies prior to transplant. Donor and recipient age were found to more strongly predict transplant failure or death, with absence of CMV antibodies and higher hepatitis C viral load also playing a role. The researchers hypothesize that all of these factors are indications of poor immunity, which would in turn lead to lower transplant success. Higher bilirubin and INR, which are associated with early death following transplant, may in turn indicate general debility in the patient. Using these factors, researchers were able to construct a model that identifies potential transplant hepatitis C patients who are at the greatest risk of early death or transplant failure.

David Greenberg | EurekAlert!
Further information:
http://www.wiley.com
http://www.interscience.wiley.com/journal/livertransplantation

More articles from Studies and Analyses:

nachricht Physics of bubbles could explain language patterns
25.07.2017 | University of Portsmouth

nachricht Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

CCNY physicists master unexplored electron property

26.07.2017 | Physics and Astronomy

Molecular microscopy illuminates molecular motor motion

26.07.2017 | Life Sciences

Large-Mouthed Fish Was Top Predator After Mass Extinction

26.07.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>