Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Long-term outcomes for liver transplantation due to hepatitis C


A new study on liver transplants necessitated by the hepatitis C virus (the most common indication for this type of transplant) found that long-term outcomes are similar to patients receiving transplants due to other diseases. It was the first study to examine long-term transplantation results in hepatitis C patients and to identify risk factors that might lead to transplant failure or death.

The results of this study appear in the September 2004 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). The journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience at

Unlike other liver diseases, hepatitis C infection commonly recurs in transplant patients. Although previous studies had shown that short-term transplantation survival rates for hepatitis C patients were similar to patients undergoing transplants for other indications, a recent analysis of the United Network for Organ Sharing (UNOS) database suggested that five-year transplant outcomes may be poorer for hepatitis C patients. The current study utilized the Liver Transplantation Database, which was established in 1990 by the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) to collect data on patients being evaluated for liver transplants.

Led by Michael Charlton, M.D. of the division of Gastroenterology & Hepatology at the Mayo Clinic in Rochester MN, researchers examined the records of 165 patients with hepatitis C who underwent liver transplants and were followed for up to 12 years post transplant. They found that these patients had 10-year outcomes similar to patients undergoing liver transplants for other reasons, that the most common cause of death or transplant failure in these patients was due to recurrence of hepatitis C, and that risk of transplant failure increased over time.

In addition, researchers examined a number of factors to see if they could be used to predict transplant success. These included recipient age, donor age, bilirubin, INR (a measure of blood-clotting capability), and viral load and the presence of cytomegalovirus (CMV) antibodies prior to transplant. Donor and recipient age were found to more strongly predict transplant failure or death, with absence of CMV antibodies and higher hepatitis C viral load also playing a role. The researchers hypothesize that all of these factors are indications of poor immunity, which would in turn lead to lower transplant success. Higher bilirubin and INR, which are associated with early death following transplant, may in turn indicate general debility in the patient. Using these factors, researchers were able to construct a model that identifies potential transplant hepatitis C patients who are at the greatest risk of early death or transplant failure.

David Greenberg | EurekAlert!
Further information:

More articles from Studies and Analyses:

nachricht Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung

nachricht High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Ice shelf vibrations cause unusual waves in Antarctic atmosphere

25.10.2016 | Earth Sciences

Fluorescent holography: Upending the world of biological imaging

25.10.2016 | Power and Electrical Engineering

Etching Microstructures with Lasers

25.10.2016 | Process Engineering

More VideoLinks >>>