"Other studies have indicated a benefit for heart attack patients in beginning treatment with statins relatively early, so today the standard practice is to prescribe them upon discharge," says R. Scott Wright, M.D., the Mayo Clinic cardiologist who was the studys lead investigator in North America. "Our new findings suggest they should be given even earlier, as soon as the patient arrives at the hospital."
The PRINCESS Trial (The PRevention of Ischemic EveNts by Early Treatment of CErivaStatin Study) was designed to test whether very early initiation of statin therapy in hospitalized heart attack patients would prevent deaths and additional heart attacks and reduce the need for bypass surgery or angioplasty.
Within 48 hours of hospitalization, 3,605 patients at 260 medical centers in Europe, Israel, Canada and the United States were randomly assigned to receive either cerivastatin, a potent statin agent, or a placebo. Neither patients nor their physicians knew whether they were receiving the statin or the sugar pill initially, but all of the patients were switched to the statin after three months. Because statins had been proven beneficial as a later-term treatment, withholding the cholesterol-lowering medication for a prolonged period would have been unethical. In the midst of the study, however, cerivastatins manufacturer withdrew it from the market due to safety concerns, so the researchers were only able to follow the participants for 4.5 months.
Lee Aase | EurekAlert!
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Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
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Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
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At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
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