Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Needle-free anthrax vaccine shows promise in animal studies

26.08.2004


Researchers have developed a powdered form of an anthrax vaccine that could potentially be inhaled through the nose and eliminate the need for needle injections. The new vaccine, which appears promising in preliminary animal studies, may offer a faster and easier way to protect the general population as well as soldiers on the battlefield in the event of a deadly bioterror attack, the researchers say.



The development, a joint project of BD Technologies and the U.S. Army Medical Research Institute of Infectious Disease, was described today at the 228th national meeting of the American Chemical Society, the world’s largest scientific society.

The vaccine represents a growing pipeline of needle-free drug delivery technologies that are being developed for consumers, such as the FluMistTMintranasal vaccine currently sold to combat influenza. Considered the next generation anthrax vaccine, the new formulation is based on an anthrax recombinant protective antigen (rPA) and can be formulated as a dry powder and self-administered through the nose using a novel, disposable powder delivery device, the researchers say.


The standard delivery for anthrax vaccination is through subcutaneous and intramuscular administration of a liquid formula using conventional needles and syringes, but this method has several drawbacks when employed for mass vaccination, including accidental needle-stick injury, the need for highly trained healthcare professionals and painful injections, the scientists say.

"Our intranasal powder vaccine discovery may provide a highly effective, more flexible, mobile and easy-to-use method of administering the anthrax vaccine in clinical and field settings," says the project’s lead investigator, Vince Sullivan, Ph.D., a chemist with BD Technologies’ Advanced Drug Delivery group in Research Triangle Park, N.C.

The vaccine has not yet been tested in humans, and additional animal studies are needed, but clinical trials could be possible within the next two to three years, investigators say.

In laboratory tests using rabbits exposed to a lethal dose of inhalation anthrax, nasal immunization with the powder resulted in an 83 to 100 percent survival rate, similar to the protection offered by the injectable formulation, according to a key researcher on the project, Ge Jiang, Ph.D., a pharmaceutical scientist with BD Technologies.

Initial data indicates that the powdered formulation of the rPA antigen, a genetically engineered protein, is also more stable than the liquid version and can withstand wider temperature extremes, allowing it to be stockpiled for longer periods and in more extreme conditions without the need for refrigeration, the researchers say.

Conventional anthrax vaccines, derived from Bacillus anthracis bacteria, require six doses over the course of an 18-month period, with annual booster injections recommended thereafter. It is not yet known how many times and at what dose the new vaccine will need to be administered to maintain protection, the researchers say, adding that this issue is being investigated.

"This is not a cure for anthrax, but may be a better means of protecting at-risk populations from infection," Sullivan explains.

Anthrax vaccine administration is now mandatory for military personnel sent to areas with high risk of exposure and recommended for other groups, including some laboratory and postal workers.

Inhalation anthrax can be fatal if untreated. Doctors currently provide antibiotics once infection has occurred, but treatment must be initiated early to be effective. In addition to improving prevention methods, researchers are continuing to try to develop better drugs to block the deadly bacterium once a person has been exposed.

The American Chemical Society is a nonprofit organization, chartered by the U.S. Congress, with a multidisciplinary membership of more than 159,000 chemists and chemical engineers. It publishes numerous scientific journals and databases, convenes major research conferences and provides educational, science policy and career programs in chemistry. Its main offices are in Washington, D.C., and Columbus, Ohio. Mark T. Sampson

Michael Bernstein | EurekAlert!
Further information:
http://www.acs.org

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>