Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The Hyperspectral Imaging Endoscope: A New Tool For Non-Invasisve In Vivo Cancer Detection

10.08.2004


A newly designed endoscope, capable of providing sub-second polarized spectral images of tissue in vivo (in the body), allows physicians and surgeons to non-invasively survey and sample an entire area without actually removing tissue, and may offer hope as a new tool for detecting cancer early. Researchers from Cedars-Sinai Medical Center in Los Angeles and Carnegie Mellon University in Pittsburgh describe the instrument’s capabilities and clinical applications in the July 2004 issue of Progress in Biomedical Optics and Imaging.

The new device, named the Hyperspectral Imaging Endoscope (HSIE), is a standard medical endoscope enhanced with a customized imaging fiber. Working together with a camera, a laptop computer and a tunable light source covering the visible and near-infrared range, the HSIE system is capable of acquiring rapid spectral images of tissues, allowing physicians to non-invasively survey and sample an entire area of tissue in vivo (within the body). Compared to traditional biopsy where a small amount of tissue is removed and then examined in a laboratory, the HSIE system provides a non-contact method of gaining as much information as possible about an area without removing any tissue.

The system is relatively simple and based on the intrinsic properties of tissue and light, explains Daniel Farkas, Ph.D., Director of the Minimally Invasive Surgical Technologies Institute at Cedars-Sinai, and one of the study authors. “When light impacts tissue, it gives back a certain scattering pattern with spectral oscillations depending on the size of the scattering object. This pattern gives us a relatively quantitative idea whether or not a tissue area contains cancerous cells since the nuclei of cells in pre-cancerous and cancerous tissues are enlarged. The theory and spectroscopy have been beautifully worked out by our colleagues in Boston and Los Alamos, and we have now moved this type of investigation into the endoscopic imaging domain.”



The pilot study using the HSIE system involved examining epithelial tissue derived from lung cancer specimens. Currently the number one cause of cancer death worldwide, lung cancer is difficult to detect in its early stages and often isn’t found until after it has spread.

At the University of Pittsburgh Medical Center and Allegheny General Hospital, the two clinical sites where the first version of the HSIE instrument was tested, data were gathered from patients who had been treated previously for lung cancer and were to undergo an endoscopic examination to see if the cancer had returned. The area to be biopsied in the traditional way by the surgeon was first scanned using the HSIE, and then sent to the laboratory. The result of the pathological examination was then treated as “ground truth.” According to Dr. Farkas, there was a good correlation between the HSIE imaging and the pathologists’ diagnoses.

Based on the experience of physicians participating in the pilot study, Dr. Farkas anticipates that the medical community will embrace the new endoscope in its practices. “Physicians can use their own endoscope of choice exactly as they have before. By using this additional fiber, they’ll be able to have either two kinds of images on separate screens or overlay the spectrally classified image onto the regular image. In early acceptance stages, this could only guide biopsy, but as the matches with pathology are confirmed, the true diagnostic value of HSIE could be established.”

Dr. Farkas, a biophysicist and past Fulbright scholar, is the vice chair for research of Cedars-Sinai’s Department of Surgery as well as director of the Minimally Invasive Surgical Technologies Institute, which was formed in May 2002 to pursue the development and application of advanced technologies in surgery.

While epithelial tissue is the primary application, Dr. Farkas said the HSIE system can also be used for gastrointestinal investigations and maybe even for breast duct endoscopy.

“Surgery is clearly gravitating to the minimally invasive arena. The technology we employed in building the HSIE system gives us a great opportunity to improve a number of important components of surgical intervention. We are working now on an implementation using acousto-optic tunable filters, invented for hyperspectral satellite reconnaissance. It may sound like science fiction now, but I think we may ultimately be able to use the endoscope to not only detect cancers early, but to treat them using modalities such as localized photodynamic therapy, laser ablation or gene therapy. This closer coupling, spatially and temporally, between diagnosis and treatment may be the cornerstone of future surgical intervention.”

The study was funded by the National Institutes of Health (NCI Unconventional Innovation Program, N01-CO-07119), the National Science Foundation (Major Instrumentation Grant BESOO 79483) and the Pennsylvania Department of Health (Commonwealth Universal Research Enhancement program, Tobacco Settlement Act 77-2001).

Sandra Van | Cedars-Sinai Media
Further information:
http://www.csmc.edu

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>