Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCI study finds kidney disease treatment also reduces related cardiovascular

03.08.2004


Findings point to possible therapy for chronic symptoms of diabetes

Cardiovascular ailments related to kidney diseases possibly can be avoided by blocking a newly identified enzyme that, in excess amounts, raises blood cholesterol levels and promotes arteriosclerosis, according to a UC Irvine College of Medicine study.

In a study on rats, Dr. Nick Vaziri found that controlling levels of ACAT, an enzyme that plays a critical role in cholesterol processing, improved both kidney function and the liver’s ability to remove cholesterol from the blood. The findings suggest that new drugs that control ACAT activity can potentially provide long-term benefits for people with chronic kidney diseases, such as type 2 diabetes. Study results appeared in the July 27 issue of Circulation.



“We’ve found that controlling the proliferation of this enzyme may help people with kidney disease caused by diabetes and various other conditions,” said Vaziri, a professor of medicine and physiology, and chief of nephrology and hypertension at UCI. “Some 20 million Americans have some form of kidney disease, and with diabetes rates rapidly increasing, research on these ailments has the potential to benefit many people.”

Kidney disease, which is common in people with diabetes, causes excessive leakage of protein into urine, an effect called proteinuria. While this leakage can ultimately lead to kidney failure, proteinuria also promotes a marked increase of ACAT levels, which in turn triggers the dangerously high cholesterol levels that lead to arteriosclerosis. Vaziri had shown in previous studies how proteinuria raises blood cholesterol levels.

In this study, Vaziri gave an ACAT inhibitor to rats with proteinuria. In addition to seeing a dramatic reduction of urine protein in these rats, he found that the inhibitor reduced total cholesterol, LDL cholesterol and triglyceride levels by half. At the same time, HDL cholesterol, known as “good” cholesterol, increased significantly. In addition, the treatment increased the level of an enzyme called LCAT in the blood of the treated rats with kidney disease.

The increases in HDL and LCAT are vital, Vaziri said, to limiting arteriosclerosis. In a precursor to artery hardening, “foam” cells form in the blood vessel walls by absorbing excess cholesterol from the circulating LDL, or “bad,” cholesterol. LCAT works to free this trapped cholesterol for removal and ultimate disposal into the liver by HDL. The higher LCAT levels made possible by the ACAT inhibitor drug, Vaziri added, can keep vascular buildup of cholesterol and the spread of arteriosclerosis to a minimum.

“These dramatic results show that controlling the excessive ACAT seen in proteinuria has a real impact on the cardiovascular ailments linked with kidney diseases,” Vaziri said. “The next step is to explore the effect of ACAT inhibition on people with kidney ailments to see if an effective treatment can be developed one day.”
Dr. Kaihui Liang of UCI assisted with the study.

About the University of California, Irvine: The University of California, Irvine is a top-ranked public university dedicated to research, scholarship and community. Founded in 1965, UCI is among the fastest-growing University of California campuses, with approximately 24,000 undergraduate and graduate students and about 1,300 faculty members. The third-largest employer in dynamic Orange County, UCI contributes an annual economic impact of $3 billion.

Tom Vasich | EurekAlert!
Further information:
http://www.uci.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>