Northwestern Memorial research shows an aspirin a day may not keep strokes away
Northwestern Memorial researchers have found that nearly half of patients who suffered a stroke or transient ischemic attack (TIA) after having been committed to aspirin therapy were "aspirin resistant," meaning the aspirin wasn’t producing the antiplatelet (blood-thinning) effect needed to avoid these health threats. Aspirin resistance increased when patients had been taking baby (81 mg) or enteric coated aspirin.
"Previous studies conducted at Northwestern Memorial Hospital showed the majority of patients taking low-dose or coated aspirin are not getting the desired antiplatelet effect," explains Mark J. Alberts, M.D., director of the stroke program at Northwestern Memorial Hospital. "Now, we’ve taken our research one step further and shown that aspirin resistance does, in fact, correlate with clinical events. Many patients who are committed to taking aspirin each day are still having strokes or transient ischemic attacks." Dr. Alberts recently presented these findings at the 5th World Stroke Congress in Vancouver, Canada.
Information about aspirin formulation was only available for 29 patients.
This study indicates that adult aspirin produces more blood-thinning results than baby and/or enteric coated aspirin. Results from a prior study suggested that older women were more likely to experience aspirin resistance.
A stroke or "brain attack" occurs when blood circulation to the brain becomes interrupted. The most common type of stroke, ischemic stroke, occurs when an artery narrows or a blood clot blocks blood flow in an artery supplying the brain. A clot can form because of sluggish blood flow through a vessel narrowed by fatty deposits. The goal of aspirin is to thin the blood, thereby reducing the risk of blood clots.
Stroke is the third leading cause of death in the United States. Each year, approximately 750,000 patients have a stroke and 165,000 of them die. Increasing age is a major risk factor for stroke, so as the population ages, strokes become even more common.
Co-authors include: Deborah Bergman, NP, Mary Soeding, RN, Richard Bernstein, M.D., Glenn Ramsey, M.D., and Paul Lindholm, M.D.
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