A new study finds increasing evidence a virus may play a role in breast cancer. The study, published July 12, 2004 in the online edition of CANCER, a peer-reviewed journal of the American Cancer Society, finds nearly three-quarters of a small sample of Tunisian breast cancer patients showed evidence of a virus similar to one known to cause breast cancer in mice, twice the rate seen in women in the United States. A free abstract of the study will be available via Wiley InterScience.
Viruses play a primary role in the development of several cancers, such as the human T-cell lymphotropic virus and adult T-cell leukemia/lymphoma or human herpes virus 8 (HHV8) and Kaposi sarcoma (KS). Geographic variability has also been noted in these cancer-promoting viruses. For example, KS and HHV8 are least common in the U.S. and more common in the Mediterranean and Central African regions.
Existing epidemiological evidence and animal models suggest that a virus may be involved in the development of certain breast cancers. Previous analyses of human breast tissue samples found viral sequences from the mouse mammary tumor virus (MMTV) in a large percentage of breast cancers but not in normal tissue. MMTV may be spread by a species of house mouse that is extremely common in North Africa but less so in the U.S. Studies show that some colonies of these mice are commonly infected with MMTV.
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