Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Moderate exercise and simple dietary supplements significantly reduce risk of atherosclerosis

25.05.2004


Moderate exercise in conjunction with common dietary supplements significantly reduce the risk of atherosclerosis because, combined, they boost the body’s production of nitric oxide, which protects against a variety of cardio-vascular disorders, a new UCLA study led by 1998 Nobel Laureate in medicine Louis J. Ignarro shows.



The study, "Long Term Beneficial Effects of Physical Training and Metabolic Treatment on Atherosclerosis in Hypercholesterolemic Mice," will be published the week of May 24 in the online edition of the Proceedings of the National Academy of Sciences (www.pnas.org). It found that moderate exercise reduced the development of atherosclerosis, or hardening of the arteries, in mice that are genetically prone to heart disease, because exercise alone has been shown to increase nitric oxide in the body. Adding the amino acid L-arginine and the anti-oxidants Vitamins C and E to the mix, however, significantly magnified the effect, said Ignarro, professor of molecular and medical pharmacology in the David Geffen School of Medicine at UCLA.

And what’s good for mice is good for humans, said Ignarro, who shared the Nobel Prize for his discoveries in the role that nitric oxide (NO) plays in the cardiovascular system.


"It wasn’t just exercise, it was exercise combined with two common dietary supplements," he said. "This is the first study that shows that if you exercise in addition to taking dietary supplements you have a markedly enhanced production of nitric oxide--in science, we like to call it a synergistic effect."

The researchers studied six groups of eight-week-old LDL receptor-deficient male mice with high cholesterol over 18 weeks. The mice were randomly divided into three dietary groups: one fed a high cholesterol diet alone, another fed a high cholesterol diet along with the antioxidant vitamins C and E, and a third fed a high cholesterol diet and given both the antioxidants and L-arginine. Some of the mice were also put on a swimming regimen while others did not exercise.

Researchers found that the mice from all three dietary groups lost weight and had lower cholesterol when they exercised. They also found that atherosclerotic legions were significantly reduced in the mice whose diets included the antioxidants and amino acid.

Here’s how exercise, L-arginine and vitamins C and E work together. Exercise increases the amount endothelial NO synthase, an enzyme that converts L-arginine to nitric oxide, which in turn lowers abnormally elevated blood pressure, prevents unwanted blood clotting and early inflammation associated with coronary artery disease, and protects against stroke and myocardial infarction. The antioxidant vitamins C and E work together to remove destructive oxidants from the blood stream, thereby stabilizing the nitric oxide, which can thus rise to higher levels in the blood stream and produce a more beneficial effect.

Sedentary mice fed with the supplements showed a 40 percent reduction in atherosclerosis lesions compared with the mice that were on a regular, high cholesterol diet but neither given the supplements nor put on an exercise regimen. The mice that exercised, but were not fed the supplements, showed a 35 percent reduction in the legions.

"This is interesting, because it shows that the supplements work well even in the absence of exercise," Ignarro said.

Ignarro recommends making simple lifestyle changes that include moderate exercise, eating a low-fat diet, and taking dietary supplements that are commercially available anywhere, which together can make a difference in one’s vascular health. "I would say just do it," he said. "It works in mice, it’ll work in humans."



Grants from the National Institutes of Health, the Mayo Foundation, and National Research Funds from the University of Naples supported the research.

Other researchers included Sharon Williams-Ignarro of the division of anesthesiology at the UCLA medical school; Claudio Napoli, Filomena de Nigris, Loredana Rossi, Carmen Guarino, Gelsomina Mansueto, Francesco Di Tuoro, Orlando Pignalosa, Gaetano De Rosa and Vicenzo Sica of the University of Naples in Italy; and Lilach O. Lerman of the Mayo Clinic Foundation in Rochester, N.Y.

Enrique Rivero | EurekAlert!
Further information:
http://www.ucla.edu/

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>