Variability in weight ranges and drug content of split tablet may put patients at risk of receiving too much/too little medication
Back and neck pain sufferers who divide the most frequently prescribed muscle relaxant may be getting anywhere from half to one-and-a-half times the amount of medicine they believe they are taking, suggests a new study examining the practice of tablet splitting. This may place them at an increased risk of encountering side effects such as drowsiness and fatigue from too much medication, according to the study’s primary investigator.
Researchers at the Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey, recently conducted a study to determine the level of weight variability of tablet fragments when the muscle relaxant cyclobenzaprine HCl 10 mg was split into halves with two commonly used devices -- a tablet splitter and a kitchen knife. Initiation of the study followed anecdotal reports that patients given a prescription for branded FLEXERIL® (cyclobenzaprine HCl) 5 mg tablets were being advised to split generic cyclobenzaprine HCl 10 mg tablets instead of taking the 5 mg tablet as prescribed by their physician. FLEXERIL 5 mg, approved by the U.S. Food & Drug Administration in February 2003, is comparable in efficacy to the 10 mg strength, but has been shown to be less sedating.
Cattaliya Snider | EurekAlert!
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
16.03.2018 | Earth Sciences
16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences