Chronic Fatigue Syndrome (CFS) is nearly four times as common in veterans of the first Persian Gulf War as in nonveterans, according to a new study. The study, to be published May 14, 2004 in the online edition of Muscle & Nerve, examined the possibility that genetic factors may play a role in developing the disease. The full study will be available via Wiley InterScience .
Fatigue that has no known medical cause, lasts more than six months, produces a substantial decrease of activity and is accompanied by symptoms associated with infection, as well as rheumatological, and neuropsychiatric symptoms, is known as CFS; idiopathic chronic fatigue (ICF) is fatigue without other symptoms or identifiable cause. CFS/ICF sometimes occurs in an almost epidemic fashion, such as in Gulf War veterans, but its cause is unknown. Genetic factors appear to play a role in both Gulf War veterans and civilian populations. Partial defects in one or more genes combined with environmental factors can result in conditions that include fatigue as a prominent feature. Previous studies have shown that mutations in the myoadenylate deaminase gene (AMPD1) and the carnitine palmitoyltransferase II (CPT2) gene can produce pain, stiffness, cramps or fatigue following strenuous exercise, while a genetic variant known as the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme or ACE (DCP1) gene may impact performance and endurance in trained athletes and army recruits.
In this new study, Drs.Georgirene Vladutiu of the State University of New York at Buffalo and Benjamin Natelson of UMDNJ-New Jersey Medical School evaluated DNA from blood samples collected from 49 Gulf War veterans and 61 nonveterans with CFS/IFS and 30 veterans and 45 nonveterans who were healthy. Blood samples were analyzed for mutations in the AMPD1, DCP1, and CPT2 genes. No significant differences were found in variations of the AMPD1 and CPT2 genes in any of the four groups. However, Gulf War veterans with CFS/ICF showed a higher prevalence of the D variant in the DCP1 gene. Veterans with the DD genotype (which has been associated with alcoholism and cardiac disease) were 8 times more likely to develop CFS or ICF than those with the lower prevalence II genotype.
David Greenberg | EurekAlert!
Do microplastics harbour additional risks by colonization with harmful bacteria?
05.04.2018 | Leibniz-Institut für Ostseeforschung Warnemünde
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy