Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists uncover how brain retrieves and stores older memories

07.05.2004


Scientists at The Hospital for Sick Children (Sick Kids) and UCLA have pinpointed for the first time a region of the brain responsible for storing and retrieving distant memories. This research is reported in the May 7, 2004 issue of the journal Science.



"It was previously known that the hippocampus processes recent memory, but that the hippocampus did not store memories permanently. We were able to determine that it is the anterior cingulate cortex where older, or lifelong, memories are stored and recalled," said Dr. Paul Frankland, the study’s co-lead author, a scientist in the Sick Kids Research Institute, and assistant professor of physiology at the University of Toronto.

The formation of new memories is thought to involve the strengthening of synaptic connections between groups of neurons. Remembering involves the reactivation of the same group, or network, of neurons. As memories age, the networks gradually change. Initially, memories for everyday life events appear to depend on networks in the region of the brain called the hippocampus. However, over time, these memories become increasingly dependent upon networks in the region of the brain called the cortex.


"We believe there is active interaction between the hippocampus and cortex, and that the transfer process of memories between these two regions in the brain occurs over several weeks, and likely during sleep," added Dr. Frankland, holder of the Canada Research Chair in Cognitive Neurobiology.

The researchers used a series of strategies with mice, including a mouse model with an altered form of a gene called CaMkinase II, which eliminates the ability to recall old memories, to identify the role of the anterior cingulate cortex.

"Most people define memory as their collective lifetime experiences. These memories colour who we are, yet until now, we’ve been mystified by how the brain saves and retrieves them," said Dr. Alcino Sliva, the study’s principal investigator and professor of neurobiology, psychiatry and psychology at the David Geffen School of Medicine at UCLA. "Now that we know where to look, we’re one step closer to developing drugs to target genes or processes of the brain that may be related to memory disorders."

Other authors on the paper include Dr. Bruno Bontempi, co-lead author, Dr. Lynn Talton, and Dr. Leszek Kaczmarek. The US National Institute on Aging funded the study.


The Hospital for Sick Children, affiliated with the University of Toronto, is Canada’s most research-intensive hospital and the largest centre dedicated to improving children’s health in the country. Its mission is to provide the best in family-centred, compassionate care, to lead in scientific and clinical advancement, and to prepare the next generation of leaders in child health. For more information, please visit www.sickkids.ca.

Laura Greer | University of Toronto
Further information:
http://www.utoronto.ca
http://www.sickkids.ca

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>