Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Iron-deficient infants score worse on cognitive and motor tests as teens

05.05.2004


Teens who suffered iron deficiency as infants are likely to score lower on cognitive and motor tests, even if that iron deficiency was identified and treated in infancy, a new University of Michigan study shows.



Betsy Lozoff, who has studied iron deficiency for nearly three decades, followed Costa Rican children who were diagnosed with severe, chronic iron deficiency when they were 12-23 months old and were treated with iron supplements.

She and her collaborators examined 191 children in working- to middle-class families at 5 years, 11-14 years and again at 15-17, and found the iron-deficient babies grew up to lag their peers in both motor and mental measures.


Lozoff is scheduled to present "Longitudinal Analysis of Cognitive and Motor Effects of Iron Deficiency in Infancy" at the Pediatric Academic Societies’ annual meeting in San Francisco May 3. It is one of six research projects Lozoff participated in that are scheduled for presentations at the meeting, which runs May 1-4.

Children who had good iron status as babies showed better motor skills than those who had been iron deficient, said Lozoff, director of the Center for Human Growth and Development at the University of Michigan and a professor in the U-M Department of Pediatrics and Communicable Diseases. That gap remained throughout childhood and adolescence. "There is no evidence of catch up."

But even worse were the cognitive measures: children who had previously suffered iron deficiency not only lagged behind their peers, but the difference actually increased over time. They scored about six points lower on cognitive tests at age 1-2 years, and 11 points lower at age 15-18 years.

The gap was even more pronounced for children of families with low socioeconomic status, lower stimulation in the home or mothers lower in IQ. For children with good iron status, family conditions did not seem to affect their cognitive test scores. For formerly iron deficient children, however, those in better family conditions started a little lower than peers and held there, while those in poorer family conditions started lower than their peers and then declined further.

"It looks like good iron status helps buffers a bad environment," Lozoff said, "but chronic, severe iron deficiency, combined with poor family conditions, really hurts children’s test performance."

Since this study followed children through their adolescence, Lozoff’s team wondered whether the same children accounted for the lower test scores at every age.

They looked at the good iron status group and broke their infant test scores into three levels: high, medium and low. Those children who scored well initially tended to score slightly worse later, and those who scored worse initially tended to see their scores increase later---what is described by statisticians as regression to the mean, or tending toward the average over time.

But for the iron deficient children, also split into high, medium and low infant test scores, there were decreases in test scores over time at all levels. Lozoff said this points out that regardless of where the children started on the test score spectrum, they still showed a decline as they got older.

Lozoff emphasized that these results are not a function of extreme poverty or general malnutrition. "This is a uniformly literate population," she said. "The children are at the U.S. 50th percentile for growth."

Lozoff’s collaborators on the study were Julia Smith, Tal Liberzon, Rosa Angulo-Barroso, Agustin Calatroni and Elias Jimenez.

Because this study follows children who received treatment for their iron deficiency, and yet they still showed ill effects up to adulthood, Lozoff said it emphasizes the importance of preventing infant iron deficiency in the first place.

Iron-deficiency anemia affects about 25 percent of infants worldwide and twice as many have iron deficiency without anemia. Many poor and minority children in the United States are also affected. During development, iron performs a variety of important roles. Iron is required to build myelin, which covers nerves and helps them share signals more efficiently, for example. Iron is also needed for brain chemicals, such as the neurotransmitter dopamine, which sends signals within the brain. Iron deficiency also differentially affects the hippocampus, which is involved in certain types of memory and other important processes.

Babies typically get their iron from the mother during pregnancy and from mother’s milk, but their rapid growth demands even more iron after about the first 4-6 months. Other foods infants often eat, such as soft cereals, cow’s milk and fruits, are poor sources of iron. In the United States, fortifying baby formula and cereals with iron has helped a great deal, but these have not been adopted internationally, and iron deficiency remains more common elsewhere.

Colleen Newvine | EurekAlert!
Further information:
http://aappolicy.aappublications.org/cgi/content/full/pediatrics;104/1/119
http://www.umich.edu/~chgdwww/faculty/lozoff.html
http://www.pas-meeting.org/

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>