Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

HIV Infection Progresses to AIDS Quicker in Developing Countries

28.04.2004


The progression from HIV infection to AIDS and death from AIDS is more rapid in people living in developing countries than those living in the United States and Europe, according to researchers from the Johns Hopkins Bloomberg School of Public Health, the Armed Forces Research Institute of Medical Sciences and Chiang Mai University in Thailand. The researchers tracked the length of time between HIV infection and AIDS among young Thai men. They also studied the death rate of the men 5-7 years after their HIV infection, which was higher when compared to their counterparts in developed countries. The study, “The Natural History of HIV-1 Infection in Young Thai Men After Seroconversion” is published in the May 2004 issue of the Journal of Acquired Immune Deficiency Syndrome.



“The importance of this study is that it demonstrates the survival and progression rates of HIV/AIDS from the time of HIV infection in a developing country and documents that the progression is more rapid than in the U.S. and Europe,” said Kenrad E. Nelson, MD, corresponding author and a professor in the Department of Epidemiology.

The researchers evaluated 235 men, who seroconverted during their two years of military service in the Royal Thai Army from 1991 to 1995. All of the men were drafted at the age of 21. After five to seven years, 156 were alive, 77 had died and 2 could not be located. The five-year survival rate of the study participants was 82 percent.


The median time from HIV-1 seroconversion to clinical AIDS in the Thai study participants was 7.4 years. A 2000 study by the Collaborative Group on AIDS Incubation and HIV Survival, known as CASCADE, which studied over 13,000 persons in whom the time of HIV infection was documented found that the medium time after HIV infection to the development of AIDS for persons in Europe, North America and Australia was 11 years for study participants who were 15-24 years old.

The mortality rate of the Thai men was 56.3 deaths per 1,000 person-years, or 18 percent five years after HIV-1 infection, as compared to a 9 percent mortality rate among individuals living in Western developed countries.

“These data will be very useful as treatment of HIV and opportunistic infections become more available for persons in developing countries. We will be able to measure the treatment’s effect on progression and survival after HIV infection,” said Dr. Nelson, who said that he would like to do a follow-up study on this cohort of men.


The study was supported by Cooperative Agreement DAMD17-98-2-7007 between the U.S. Army Medical Research and Material Command and the Henry M. Jackson Foundation for the Advancement of Military Medicine. Additional support came from the Johns Hopkins University Fogarty AITRP grant.

Chris Beyrer, in the Department of Epidemiology, co-authored the article, in addition to Ram Rangsin, Joseph Chiu, Chirasak Khamboonruang, Narongrid Sirisopana, Sakol Eiumtrakul, Arthur E. Brown, Merlin Robb, Cholticha Roengyutikarn and Lauri E. Markowitz.

Public Affairs media contacts for the Johns Hopkins Bloomberg School of Public Health: Kenna Brigham or Tim Parsons at 410-955-6878 or paffairs@jhsph.edu. Photographs of Kenrad Nelson and Chris Beyrer are available upon request.

Kenna L. Brigham | JHU
Further information:
http://www.jhsph.edu/

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>