Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Newer drugs more effective at curing strep throat than penicillin

05.04.2004


Study’s findings contradict long-held belief that penicillin is best for the job



Pediatricians treating a child who has strep throat should reconsider the role of penicillin given that a newer class of antibiotics called cephalosporins are three times more effective, according to a study being published in the April issue of Pediatrics. The findings will spark widespread debate, because they contradict long-established guidelines from the American Academy of Pediatrics, American Heart Association, and World Health Organization.

Strep throat is a bacterial infection that can be spread by personal contact, including coughing or sneezing, often affecting school-age children. Penicillin is considered the gold standard for treating strep throat, but pediatricians should realize that cephalosporins are more effective in killing the germs, says Janet Casey, M.D., the study’s lead author and a University of Rochester Medical Center pediatrician. Cephalosporin drugs – such as Cephalexin, Cefadroxil, and Cefprozil, Cephdinir – are oral medications that come in liquid and pill forms, and are safe for infants, children, and teens.


The new study presents findings from a meta-analysis, a review of previous studies done about the efficacy of cephalosporin drugs and penicillin. "We carefully examined 35 studies done since 1969, all of which discussed whether cephalosporin or penicillin are more effective in treating strep throat," Casey says, noting more than 7,000 children participated in the studies. "Children who have strep throat will have a superior outcome if they receive cephalosporin rather than penicillin." The findings indicate that the newer class of drugs has a more impressive bacterial cure rate.

First-generation cephalosporin drugs, such as Cephalexin and Cefadroxil, are comparable in cost to penicillin, and provide the same narrow-spectrum effect, Casey says. Using a drug that has a narrow spectrum is important because it is targeted enough to cure the bacteria, but not so strong that it causes resistance, which could lead to fostering of a super bug. In fact, one of the reasons penicillin – and its close relative, amoxicillin – remains the recommended course of treatment is because it has a very targeted effect. But, Casey says, so do many cephalosporin drugs.

Some penicillin proponents don’t spend much time in the pediatrician’s office, Casey says. "Many of these doctors aren’t in the trenches anymore seeing sick children every day," she says. "Those of us who are see how frustrating it is for families who need to come back for additional treatments, who wonder why the antibiotic their child took didn’t work.

"In my own practice, given the results of our analysis, I find it very difficult not to prescribe cephalosporin drugs to my patients," Casey says. "I am hopeful that organizations such as the American Academy of Pediatrics will review our study and revisit the guidelines."

Physicians involved with the meta-analysis approached their work cautiously, realizing that some analyses are more worthwhile than others. "If such a study is done improperly or without due care, the downside is that faulty data from previous studies will make it into the new one," Casey says. "But we employed a well-known system of identifying high-quality studies – the Jadad Score – to ensure that we were working only with high-quality data.

"We really turned these 35 studies inside out, comparing and contrasting dozens of different variables," Casey says. "For instance, we examined factors such as compliance monitoring, which ensures that a child actually took the prescribed drug. Some studies we reviewed took compliance into consideration, and some did not. When using the data from only studies in which the children were compliant in using the antibiotics, our findings were the same – cephalosporin drugs are more effective."


Michael Pichichero, M.D., a pediatrician from the University of Rochester Medical Center, served as second author on the study. He and Casey are full-time pediatricians at Elmwood Pediatrics in Rochester, N.Y. The study was not funded by an outside source.

Travis Anderson | EurekAlert!
Further information:
http://www.urmc.rochester.edu/

More articles from Studies and Analyses:

nachricht Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

Ultrathin device harvests electricity from human motion

24.07.2017 | Power and Electrical Engineering

Scientists announce the quest for high-index materials

24.07.2017 | Materials Sciences

ADIR Project: Lasers Recover Valuable Materials

24.07.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>