Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A new Twist on bone development

16.03.2004


A new research study reveals that formation of the cells that build bone tissue, called osteoblasts, is suppressed by a complicated inhibitory signal and that formation of the skeleton proceeds only after relief of the inhibition. This inhibitory signal is part of normal development, and without it, bone formation proceeds prematurely and abnormally.



A gene called Runx2 is the earliest and most specific indicator of osteoblast formation. However, Runx2 expression precedes the actual appearance of osteoblasts by about 4 days. Dr. Gerard Karsenty from Baylor College of Medicine in Houston, Texas, and colleagues were interested in determining what other regulatory molecules may be involved in this process during the delay period. They focused on proteins called Twist-1 and Twist-2 that are present in decreased amounts in people with Saethre-Chotzen syndrome, a disease characterized by overproduction of bone tissue. The researchers discovered that Twist proteins are found in Runx2-containing cells very early in development and that osteoblast development occurs only after Twist amounts decrease. Further, without Twist proteins, osteoblasts form too early and too much Twist inhibits osteoblast formation but does not influence that amount of Runx2 expression.

The researchers conclude that Twist proteins transiently inhibit osteoblast differentiation during formation of the skeleton by negatively regulating Runx2. According to Dr. Karsenty, "These results reveal an unanticipated complexity in osteoblast differentiation whose initiation is determined by the relief of an inhibition." The researchers went on to identify a novel region of the Twist proteins, named the Twist box, and characterized this region as the specific site required for interaction between the two Twist proteins and Runx2. The authors point out that some Saethre-Chotzen patients have a mutation that results in a loss of the Twist box and that this mutation could easily explain the occurrence of the disease.



P. Bialek, B. Kern, X. Yang, M. Schrock, D. Sosic, N. Hong, H. Wu, K. Yu, D.M. Ornitz, E.N. Olson, M.J. Justice, and G. Karsenty: "A Twist Code Determines the Onset of Osteoblast Differentiation"

Published in Developmental Cell, Volume 6, Number 3, March 2004, pages 423-436.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com/

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Carbon nanotube optics provide optical-based quantum cryptography and quantum computing

19.06.2018 | Physics and Astronomy

How to track and trace a protein: Nanosensors monitor intracellular deliveries

19.06.2018 | Life Sciences

New material for splitting water

19.06.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>