Genetic test sought to identify patients most likely to respond
A new anti-cancer agent, gefinitib (Iressa), recently received FDA approval for patients with advanced non-small cell lung cancer (NSCLC) after a series of clinical trials and an expanded access program led by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC). The compound is designed to target and block the activity of the tyrosine kinase enzyme that signals the epidermal growth factor receptor (EGFR), telling the cancer cells to grow, divide, and spread. Gefinitib shrunk tumors in only ten percent of the NSCLC patients, although the enzyme is believed to be present and activated in most NSCLC patients. The results raised the questions - why wasnt the drug effective in more patients and could physicians predict who would respond to the drug?
The MSKCC researchers took a retrospective review of the characteristics of their patients in the three trials to analyze the features that were associated with sensitivity to the drug. They found that gefitinib worked best in individuals who had never smoked, had a type of non-small cell lung cancer called bronchioloalveolar cell carcinoma, and were female. Their results, published in the March 15 issue of the Journal of Clinical Oncology, may provide clues to the mechanisms involved in both the drug response and in possible tobacco-related genetic changes in lung cancer. This information could help physicians select those patients who will most benefit from the drug and also provide information that could lead to development of a molecular screen to grade expression and over-expression of EGFR tyrosine kinase inhibitor, much like one used to measure HER2 neu for breast cancer patients.
Joanne Nicholas | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology