Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Biodegradable particles mimic white blood cells, target inflamed tissue, new study finds

17.12.2003


Scientists have developed biodegradable polymers that can mimic the ability of white blood cells to target inflamed blood vessel walls, according to a new study led by Ohio University researchers. The finding could be the first step in developing drugs that suppress specific sites of inflammation in medical conditions such as arthritis, heart disease and inflammatory bowel disease.



Researchers found that biodegradable beads coated with targeting molecules can travel through the bloodstream and effectively stick to the site of tissue inflammation, a symptom of various diseases, according to the study, which will be published in the Dec. 23 issue of the journal Proceedings of the National Academy of Sciences. Scientists are interested in drugs made from biodegradable polymers because they can be easily prepared, have a long shelf life and can be designed to release specific doses of medication, according to the study.

When the body suffers from a bacterial infection or a wound, the white blood cells, or leukocytes, adhere to the site to treat the problem. But in inflammatory diseases such as arthritis, heart disease or inflammatory bowel disease, leukocytes accumulate in an area where they aren’t needed and cause or progressively worsen the disease.


To address that issue, Ohio University researcher Douglas Goetz and colleagues Justin Hanes of Johns Hopkins University, Kevin Shakesheff of the University of Nottingham in England, Mohammad Kiani of the University of Tennessee Health Science Center and David Kurjiaka of Ohio University have been studying whether biodegradable particles could be used to mimic the activity of leukocytes, traveling to the exact site of the inflammatory disease in the body and delivering treatment. Conventional drugs treat pathological inflammation, but may impact healthy tissue too.

"Can we take a particle and give it the same surface chemistry as the leukocyte and make it go where the leukocyte goes?" asked Goetz, an associate professor of chemical engineering whose research is funded by the National Science Foundation and the Whitaker Foundation.

The new study suggests that in animal models, a biodegradable bead can be coated with targeting molecules and show the same level of adhesion as leukocytes. Shakesheff originally developed the bead, which is made of polylactic acid and polyethylene glycol, two polymers commonly used in other medical applications, Goetz said. This biodegradable particle was 100 times more effective at sticking to the blood vessel wall than other materials tested in previous studies, the engineer said.

The bead degrades and converts to lactic acid, a substance normally found in the body. Goetz and colleagues, using novel polymers developed by Hanes, next will test different polymers – as well as smaller nanoparticles -- that could degrade even faster in the body and offer different drug delivery options, he said. Quick degradation also could help avoid uptake by organs not intended to receive the particles, he said, a possible negative side effect of the process.

The research team also will further examine another interesting finding from the study: The biodegradable particles not only mimic the leukocyte’s ability to stick to tissue, but its tendency to roll along the blood vessel wall. Though Goetz is unsure what impact this finding will have on drug delivery at this point, "it demonstrates how well we can control these particles – not only with selective delivery, but also the type of relationship they have with the vessel wall," he said.

Goetz, who next will study the drug delivery potential for chronic inflammatory conditions, hopes that the combined cell adhesion/drug delivery approach to addressing inflammation-related illnesses will progress in the next 10 years. Other scientists are making progress in creating a targeted drug delivery process to eradicate cancerous tumors, but applying such concepts to inflammatory diseases will call for some fine-tuning, he said. "Applying this to inflammation is a whole different ball game," Goetz said. "A patient probably won’t die from arthritis; it’s a much more subtle problem."

Other collaborators on the study are Harshad Sakhalkar, an Ohio University graduate student in chemical engineering; Milind Dalal, a former Ohio University graduate student in chemical engineering; Aliasger Salem of the University of Nottingham; Ramin Ansari of the University of Tennessee Health Science Center; and Jie Fu of Johns Hopkins University.


Contact: Douglas Goetz, 740-593-1494, goetzd@ohio.edu.

Andrea Gibson | EurekAlert!
Further information:
http://www.ohio.edu/researchnews/

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>