Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cell death promotes learning growth

27.11.2003


Background



The hippocampal formation has long been associated with the execution of higher-order cognitive functions, and impairment of this structure following severe stress and aging has been linked to cognitive disturbances. In order to understand the involvement of the hippocampal formation in the mediation of normal and pathological behaviors, much attention has recently been devoted to hippocampal neurogenesis. The dentate gyrus of the hippocampal formation has the ability to generate new neurons throughout the entire life. Surviving de novo produced cells develop into granule neurons and integrate into the functional circuitry. Neurogenesis has been proposed to play a role in hippocampal-mediated learning and has been implicated in the appearance of behavioral pathologies associated with the hippocampal formation.

Aim of the work


Although evidence suggest that neurogenesis play a role in spatial learning, the effect of learning on cell proliferation remains unclear. The authors generated and tested the hypothesis that different phases of spatial learning measured in the Morris water maze have distinct actions on cell proliferation. In this task, two phases of learning can be distinguished: an early phase during which performance improves rapidly, and a late phase during which asymptotic levels of performance are reached. These two phases seem to involve different brain processes and consequently may differentially influence neurogenesis.

Results

The authors demonstrated that the late phase of learning has a multifaceted effect on neurogenesis depending on the birth date of new neurons. The number of newly born cells increased contingently with the late phase and a large proportion of these cells survived for at least 4 weeks and differentiated into neurons. In contrast, the late phase learning decreased the number of newly born cells produced during the early phase. This learning-induced decrease in the number of newly generated cells results most probably from the death of the cells. Strikingly, cell death and not proliferation was positively correlated with performance in the water-maze. Thus, rats with the lowest cell death were less able to acquire and use spatial information than those with the highest cell death.

Conclusion

The results reveal a complex modulation of learning on brain plasticity, which induces death and proliferation of different populations of cells. Most importantly, they introduce the notion that removing neurons from the adult brain can be an important process in learning and memory and a novel mechanism through which neurogenesis may influence normal and pathological behaviors.


Citation source: Molecular Psychiatry 2003 Volume 8, number 12, pages 974-982.

AUTHORS: Matè Daniel Döbrössy*, Elodie Drapeau*, Catherine Aurousseau, Michel Le Moal, Pier Vincenzo Piazza, Djoher Nora Abrous * have equally contributed to the work

INSERM U259, University of Bordeaux, Domaine de Carreire, Bordeaux, France

For further information on this work, please contact Dr. Nora Abrous, INSERM U.588, Institut François Magendie, Rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France. Tel: 33-5-57-57-36-86, Fax: 33-5-56-96-68-93, E-mail: nora.abrous@bordeaux.inserm.fr

Aimee Midei | EurekAlert!
Further information:
http://www.naturesj.com/mp/
http://www.nature.com/mp

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>