Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study shows combining gene therapy and radiation holds promise

24.11.2003


A novel approach that combines gene therapy and radiation therapy for treating prostate cancer has shown promising results for its safety and effectiveness, according to Henry Ford Hospital researchers.



The study, published in this month’s edition of Cancer Research, shows that patients experienced no significant side effects when treated with gene therapy and radiation therapy. It also showed that the treatment lowered patients’ prostate-specific antigen (PSA) and eliminated the cancer in many of them.

PSA is a protein produced by the prostate. By measuring its level, doctors can monitor prostate cancer growth as well as the effectiveness of standard and investigational treatments.


All 15 patients enrolled in the study experienced significant declines in their PSA – from an average of 12 to below one – and 10 of them were cancer-free after one year. The patients had an aggressive form of prostate cancer that, if treated with standard radiation therapy alone, would likely recur and possibly spread.

While the results are encouraging, researchers say more research is needed and the novel treatment needs to be tested in a larger randomized clinical trial, which is planned for next year.

"Our belief is that gene therapy could make conventional cancer therapies such as radiation therapy more effective," says Svend Freytag, Ph.D., division head of Henry Ford’s Radiation Oncology Research and lead author of the study.

The study is the first of its kind in the world to test the safety and effectiveness of a replication-competent virus in combination with radiation therapy. The replication-competent virus used in the treatment – the one associated with the common cold – has been shown to enhance the gene therapy’s effectiveness by spreading the gene therapy to nearby cells after it is injected into the prostate.

The virus kills the cancerous cells, but leaves normal ones undamaged. When combined with the gene therapy, it enhances the virus’ effect by rendering the malignant cells sensitive to radiation therapy.

An estimated 220,900 new cases of prostate cancer will be diagnosed this year, and nearly 29,000 men will die of it, according to the American Cancer Society. Prostate cancer is the second-leading cause of cancer death in men, after lung cancer.

Dwight Angell | EurekAlert!
Further information:
http://www.henryfordhealth.org/

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>