By screening the genomes of mice with heart failure, Duke University Medical Center researchers have discovered multiple stretches of DNA containing genes that modify the hearts pumping ability and survival with the disease. The findings could point researchers to genes that determine the severity of heart failure in patients, according to the Duke team.
Douglas A. Marchuk, PhD
Photo Credit: Duke University Medical Center
"Our goal is to find novel genes that modify human heart failure by letting the mouse point us in the right direction," said Duke cardiologist Howard Rockman, M.D., noting that 99 percent of mouse genes are shared by humans. "Such genes would provide us the means to identify those heart failure patients having subtle genetic differences that make them more susceptible to poor outcomes."
That information would allow physicians to identify those patients in need of the most aggressive therapies and provide new targets for drug development, Rockman said. He and geneticist Douglas Marchuk, Ph.D., also of Duke, reported their findings in the Dec. 1, 2003, issue of Human Molecular Genetics. The work was supported by the National Institutes of Health, the French Federation of Cardiology and the Burroughs Wellcome Fund.
Kendall Morgan | dukemed news
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Physics and Astronomy
23.05.2017 | Life Sciences
23.05.2017 | Medical Engineering