Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genes Control Severity of Heart Failure, Study Finds

17.11.2003


By screening the genomes of mice with heart failure, Duke University Medical Center researchers have discovered multiple stretches of DNA containing genes that modify the heart’s pumping ability and survival with the disease. The findings could point researchers to genes that determine the severity of heart failure in patients, according to the Duke team.


Douglas A. Marchuk, PhD
Photo Credit: Duke University Medical Center



"Our goal is to find novel genes that modify human heart failure by letting the mouse point us in the right direction," said Duke cardiologist Howard Rockman, M.D., noting that 99 percent of mouse genes are shared by humans. "Such genes would provide us the means to identify those heart failure patients having subtle genetic differences that make them more susceptible to poor outcomes."

That information would allow physicians to identify those patients in need of the most aggressive therapies and provide new targets for drug development, Rockman said. He and geneticist Douglas Marchuk, Ph.D., also of Duke, reported their findings in the Dec. 1, 2003, issue of Human Molecular Genetics. The work was supported by the National Institutes of Health, the French Federation of Cardiology and the Burroughs Wellcome Fund.


Heart failure -- a condition characterized by the inability of the heart muscles to pump enough blood to the body’s tissues -- affects nearly 5 million patients in the U.S. and is a growing public health concern, Rockman said. Despite the development of novel treatments, the one-year mortality rate for patients with heart failure is as high as 42 percent.

Yet heart failure patients exhibit significant variability in quality of life and survival with the condition, he said. "Following a heart attack, some patients are able to return to their normal lifestyle, while others are horribly debilitated," said Rockman.

In their study, the researchers set out to uncover chromosomal regions containing heart failure modifier genes responsible for some of that difference.

The researchers mated males of one mouse strain that had genetic mutations that conferred a very reproducible and severe form of heart failure, with females of another healthy mouse strain. Some of the resulting offspring exhibited severe heart failure, while others inherited genes from their healthy mothers that protected them from the disorder. By screening the genomes of the offspring, the team uncovered those genetic regions that modified the severity of heart failure.

The researchers found two genetic regions -- one on chromosome 13 and another on chromosome 18 -- linked to heart function and survival with heart failure. An additional region on chromosome 2 affected cardiac function with no effect on survival, while another on chromosome 4 influenced survival without impacting heart function in mice with heart failure, the team reported.

"The immediate cause of death for patients with heart failure can be the consequence of two different mechanisms: gradual pump failure or sudden death due to irregularities in heartbeat," Rockman said. "That some genes affect cardiac function without affecting survival and vice versa suggests that distinct genes may underlie the gradual decline in heart function characteristic of heart failure and the risk of sudden death associated with the disease."

The next step will be to identify the precise genes within these regions that modify heart failure outcome, using the sequenced mouse and human genomes to identify likely candidates, said the researchers.

Additional researchers on the study include first author Philippe Le Corvoisier, M.D., Hyun-Young Park, M.D., and Kerri Carlson, all of Duke University Medical Center. The team has already begun a collaboration with others at Duke to identify genes that affect outcome in patients with heart failure.

Kendall Morgan | dukemed news
Further information:
http://dukemednews.org/news/article.php?id=7204

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>