Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Growth hormone-deficient young adults need larger replacement doses than older adults

06.11.2003


Young adults who received growth hormone treatment as children for deficiencies in producing that essential hormone likely will need continued treatment for years and at higher doses than doctors now prescribe, a new multi-center North American study concludes.



Higher doses of the hormone should help protect such patients from excessive and eventually crippling declines in the density of their bones and from higher blood levels of harmful fats that could promote heart disease, researchers say. Earlier reports suggested growth hormone also helped maintain healthy muscle mass and lessened depression, a common complaint among patients.

A report on the study, conducted over two years at 12 U.S. and five Canadian medical centers, appears in the November issue of the Journal of Clinical Endocrinology & Metabolism.


Dr. Louis Underwood, professor of pediatrics at the University of North Carolina at Chapel Hill School of Medicine, led the research. Co-authors of the paper were Drs. Kenneth M. Attie and Joyce Baptista of Genentech Inc. of San Francisco and the Genentech Collaborative Study Group.

"We did this randomized, double-blind, placebo-controlled trial to improve our understanding of what doses we should give young adults who need treatment," said Underwood. "We believe our findings will change clinical practice in the United States and abroad."

Typically, doctors treat growth hormone-deficient children with hormone doses that reach a peak in late adolescence when the naturally secreted compound reaches its maximum in healthy children, he said. As patients age into adulthood, clinicians often stop treatment to determine whether there is a continued need. If so, treatment is restarted at significantly lower doses since older adults need less growth hormone and cannot tolerate it as well as children.

"Besides the placebo, which is inactive, we tested a dose of 25 micrograms per kilogram of body weight per day and also a dose that was half that large," Underwood said. "The 25 microgram dose is about half of what is used in children."

The medical scientists studied 39 men and 25 women, all under age 35, and looked especially at what happened to their bone mineral density, depending on whether or not they received growth hormone and how much.

"Compared with the placebo group, patients who got 12.5 micrograms showed better bone mineral density after two years," Underwood said. "Those who received 25 micrograms per kilogram daily showed an even greater and more sustained effect."

Both growth hormone-treated groups had similar changes in body composition at six months -- decreased fat and increased lean mass -- but some improvements were later lost in the lower-dose group, he said.

"A significant decrease in low-density lipoprotein cholesterol, which is believed to be bad for a person’s health, was seen only in the higher growth hormone dose group," Underwood said. "We did not observe significant changes in quality of life or echocardiograph measures."

Adverse effects among study groups were about the same except that the hormone-treated groups showed more swelling, a common side effect of such treatment in adults, he said.

Genentech supported the research. Collaborating institutions in the United States included Children’s Hospital Medical Center in Cincinnati, Kansas Medical Center, the Medical College of Wisconsin, the Oregon Health Sciences University, Stanford University and the universities of California at Los Angeles and Michigan. Canadian institutions included Children’s Hospital in Winnipeg, Children’s Hospital of Western Ontario, Central University Hospital in Sherbrooke, Quebec, the Research Center of Hotel-Dieu of Montreal and Central Hospital of Laval University in Ste.-Foy, Quebec.

In the 1970s, Dr. Judson J. Van Wyk, Underwood and UNC colleagues purified a compound known as IGF-1 and developed an assay for it. IGF-1, or insulin-like growth factor 1, is a growth-hormone-dependent protein that mediates many of the growth-promoting actions of growth hormone.

Now, doctors around the world monitor the effect of growth hormone therapy in hormone-deficient adults by testing their levels of IGF-1, which is made throughout the body but chiefly in the liver. The brain’s pea-sized pituitary gland produces growth hormone.

David Williamson | EurekAlert!
Further information:
http://www.med.unc.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Bare bones: Making bones transparent

27.04.2017 | Life Sciences

Study offers new theoretical approach to describing non-equilibrium phase transitions

27.04.2017 | Physics and Astronomy

From volcano's slope, NASA instrument looks sky high and to the future

27.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>