Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New study shows possible role of SERMs in future menopausal hormone therapy

06.11.2003


New research published this month in the journal Endocrinology highlights a possible safe, future treatment for postmenopausal women. The research, which was conducted by doctors at Laval University in Quebec, Canada, found that EM-652, a selective estrogen receptor modulator (SERM) given in association with an estrogen, may be effective at controlling hot flashes and preventing breast, uterine and ovarian cancer as well as osteoporosis in postmenopausal women.



Additionally, the combination shows promise in potentially helping with brain function and preventing Alzheimer’s disease with no risk or negative effect.

Over the past year, millions of women have become afraid and confused about the risks and benefits of hormone replacement therapy following the results of the Women’s Health Initiative Study (WHI), which found that women on the combination replacement estrogen and progestin have an increased risk (26 percent) of developing breast cancer. In light of these findings, the medical community has worked to determine the best way to treat the symptoms and risks of menopause, while researchers search for alternative therapies for the millions of women who used combination hormones to treat their menopausal symptoms, such as hot flashes. Dr. Fernand Labrie and his colleagues in Quebec, Canada have now demonstrated that the next generation of menopausal therapy may lie in a combination of SERMs and estrogen, with the SERM preventing the potential risk of breast cancer caused by the estrogen.


Through three separate studies on rats, Dr. Labrie and his team sought to validate the promise of EM-652 as a postmenopausal treatment. The researchers treated different groups of rats with EM-652 and estrogen and measured the impact on the mammary gland and uterus. One study examined the effects of 17beta-estradiol, an estrogen and EM-652 alone and in combination.

The findings showed that when administered together, the estrogen was blocked in the mammary gland and uterus, while EM-652 protected bone and decreased serum lipids. Since EM-652 has little or no access to the brain, it should not prevent estrogen from exerting its beneficial effects on hot flashes, memory and cognition and potentially preventing Alzheimer’s disease. At the same time, EM-652 blocks the negative effects of estrogen in the peripheral tissues, including the mammary gland and uterus.

"EM-652 in combination with estrogen may offer a novel approach to treating postmenopausal women," explained Dr. Labrie. "If our findings in rats are duplicated in women, this tissue-specific hormone replacement therapy could meet the most important needs of women at menopause, which include control of hot flashes, improvement of cognitive function and memory, decreased risk of Alzheimer’s disease and, most importantly, the prevention of three serious cancers-breast, ovarian and uterine-as well as bone loss."

Endocrinology is one of four journals published by The Endocrine Society.

Marisa Lavine | EurekAlert!
Further information:
http://www.endo-society.org

More articles from Studies and Analyses:

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht Do microplastics harbour additional risks by colonization with harmful bacteria?
05.04.2018 | Leibniz-Institut für Ostseeforschung Warnemünde

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

European particle-accelerator community publishes the first industry compendium

26.04.2018 | Physics and Astronomy

Multifunctional bacterial microswimmer able to deliver cargo and destroy itself

26.04.2018 | Life Sciences

Why we need erasable MRI scans

26.04.2018 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>