Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New study shows possible role of SERMs in future menopausal hormone therapy

06.11.2003


New research published this month in the journal Endocrinology highlights a possible safe, future treatment for postmenopausal women. The research, which was conducted by doctors at Laval University in Quebec, Canada, found that EM-652, a selective estrogen receptor modulator (SERM) given in association with an estrogen, may be effective at controlling hot flashes and preventing breast, uterine and ovarian cancer as well as osteoporosis in postmenopausal women.



Additionally, the combination shows promise in potentially helping with brain function and preventing Alzheimer’s disease with no risk or negative effect.

Over the past year, millions of women have become afraid and confused about the risks and benefits of hormone replacement therapy following the results of the Women’s Health Initiative Study (WHI), which found that women on the combination replacement estrogen and progestin have an increased risk (26 percent) of developing breast cancer. In light of these findings, the medical community has worked to determine the best way to treat the symptoms and risks of menopause, while researchers search for alternative therapies for the millions of women who used combination hormones to treat their menopausal symptoms, such as hot flashes. Dr. Fernand Labrie and his colleagues in Quebec, Canada have now demonstrated that the next generation of menopausal therapy may lie in a combination of SERMs and estrogen, with the SERM preventing the potential risk of breast cancer caused by the estrogen.


Through three separate studies on rats, Dr. Labrie and his team sought to validate the promise of EM-652 as a postmenopausal treatment. The researchers treated different groups of rats with EM-652 and estrogen and measured the impact on the mammary gland and uterus. One study examined the effects of 17beta-estradiol, an estrogen and EM-652 alone and in combination.

The findings showed that when administered together, the estrogen was blocked in the mammary gland and uterus, while EM-652 protected bone and decreased serum lipids. Since EM-652 has little or no access to the brain, it should not prevent estrogen from exerting its beneficial effects on hot flashes, memory and cognition and potentially preventing Alzheimer’s disease. At the same time, EM-652 blocks the negative effects of estrogen in the peripheral tissues, including the mammary gland and uterus.

"EM-652 in combination with estrogen may offer a novel approach to treating postmenopausal women," explained Dr. Labrie. "If our findings in rats are duplicated in women, this tissue-specific hormone replacement therapy could meet the most important needs of women at menopause, which include control of hot flashes, improvement of cognitive function and memory, decreased risk of Alzheimer’s disease and, most importantly, the prevention of three serious cancers-breast, ovarian and uterine-as well as bone loss."

Endocrinology is one of four journals published by The Endocrine Society.

Marisa Lavine | EurekAlert!
Further information:
http://www.endo-society.org

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>