Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cellular fat sensor slows heart disease

17.10.2003


A cellular sensor of dietary fats slows the development of lesions that lead to heart disease, a Salk Institute study has found.



The study, which appears in the Oct. 17 edition of Science and is posted on the journal’s web site, uncovers a unique pathway that significantly curbs the development of atherosclerosis - the accumulation of fatty deposits on arterial walls. The pathway could be used to develop drugs to treat heart disease, currently the number one killer of Americans.

Ronald Evans, the March of Dimes Chair in Molecular and Developmental Biology at the Salk Institute, research fellow Chih-Hao Lee and colleagues found that the regulatory molecule, PPAR-delta (short for peroxisome proliferator-activated receptor), plays a powerful part in the body’s inflammatory response to the beginning phases of atherosclerosis.


"Immune cells promote inflammation, which stimulates the transport and absorption of fat that triggers the early stages of heart disease," Evans said. "Our study uncovered the molecular switch that regulates this process and reveals how the inflammatory response, designed to fend off invading agents, can go awry and encourage atherosclerosis and heart disease."

The researchers found that the PPAR-delta switch cut heart disease in half. It does this by disrupting a cellular signal that controls the inflammatory response.

Activation of PPAR-delta by a fat-like drug reduces inflammation and discourages the growth of atherosclerotic plaques.

"The lesions that cause atherosclerosis are very complex, and are aggravated," said Evans. "We believe that PPAR-delta normally acts as a molecular soldier to guard against inflammation and disease. Unfortunately, these good effects are compromised by high fat diets, poor exercise, infections and stress. Chemicals that regulate the activity of PPAR-delta could form the basis of a new drug to reduce atherosclerosis and therefore be a possible therapy for heart disease."

Heart disease is the number one health threat to Americans; about one million die from some form of heart disease every year. The Howard Hughes Medical Institute and the National Heart Lung and Blood Institute supported the researchers’ work. Evans’ collaborators at the Scripps Research Institute include Drs. Linda Curtiss and William Boisvert.


The Salk Institute for Biological Studies, located in La Jolla, Calif., is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and conditions, and the training of future generations of researchers. Jonas Salk, M.D., founded the institute in 1960 with a gift of land from the City of San Diego and the financial support of the March of Dimes Birth Defects Foundation.

Andrew Porterfield | EurekAlert!
Further information:
http://www.salk.edu/

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>