Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Study shows brain activity influences immune function


Staying healthy may involve more than washing hands or keeping a positive attitude. According to a new study from the University of Wisconsin-Madison, it also may involve a particular pattern of brain activity.

By monitoring activity levels in the human brain’s prefrontal cortex, the researchers demonstrate for the first time that people who have more activity in the left side of this area also have a stronger immune response against disease. The findings, soon to be published in the online edition of the journal Proceedings of the National Academy of Sciences, pinpoint one of the mechanisms underlying the link between mental and physical well-being.

Numerous scientific studies show that keeping a positive attitude can keep a person healthy, says Richard Davidson, a UW-Madison neuroscientist and senior author of the paper. But he adds that the reasons why this connection exists are poorly understood.

By turning to the brain - an organ that sends signals that guide emotional response - Davidson and his group have identified one possible explanation: activity in the prefrontal cortex, a region of the brain long associated with affective style, or how a person responds emotionally to an event.

"Emotions play an important role in modulating bodily systems that influence our health," says Davidson. "We turned to the brain to understand the mechanisms by which the mind influences the body."

While earlier studies have linked emotional and physical health, as well as brain activity and affective style, Davidson says none have established a direct link between brain activity and immune function.

The latest study by the UW-Madison group demonstrates this connection.

For the study, the researchers worked with 52 individuals between the ages of 57 and 60 who were recruited from the Wisconsin Longitudinal Study - a long-term study of more than 10,000 people who graduated from Wisconsin high schools in 1957. Specifically, the scientists wanted to know if people who showed more activity in the left side of the prefrontal cortex - a part of the brain associated with positive emotional responses - also showed greater immunity to the influenza virus after vaccination.

To answer this question, the researchers vaccinated all the subjects against the flu virus. Before vaccination, they measured the study participants’ brain activity, both at a baseline state and during emotion eliciting memory tasks. During these tasks, the participants were asked to recall two events - one that made them feel intensely happy and another that left them feeling intensely sad, fearful or angry. As the respondents focused on the emotion experienced for one minute, the researchers measured the electrical activity in both the right and left sides of the prefrontal cortex.

Previous studies, notes Davidson, have shown that individuals with greater activity on the right side of this brain region tend to have a more negative affective style, which can cause these individuals to respond inappropriately to emotional events.

The researchers collected these prefrontal cortex activity levels again after the subjects spent five minutes writing about the particular events. At this time, they also measured the participants’ eyeblink reflex in response to sudden noises. This measure, explains Davidson, provides a convenient and objective way to measure how negatively or positively a person reacts to a stimulus.

Three times in the six months following vaccination, the researchers collected serum samples from each subject to track the number of flu-fighting antibodies in the blood, which can determine immune function.

Six months after being vaccinated against the flu virus, the subjects who had greater activity in the left side of the prefrontal cortex, instead of the right side, also had a greater rise in the number of antibodies for influenza, says Davidson.

"This study establishes that people with a pattern of brain activity that has been associated with a positive affective style are also the ones to show the best response to the flu vaccine," says the Wisconsin researcher. "It begins to suggest a mechanism for why subjects with a more positive emotional disposition may be healthier."

This research was supported by grants from the National Institute of Mental Health and the John D. and Catherine T. MacArthur Foundation Research Network on Mind-Body Interaction.

Emily Carlson, 608-262-9772,

Richard Davidson | EurekAlert!
Further information:

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>