Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

USC researchers identify tumor suppressor that manages cellular cleaning and recycling proceses

07.07.2008
Findings provide insight into regulation of trafficking pathways
Researchers at the University of Southern California (USC) have identified a specific tumor suppressor that manages membrane traffic routes for cellular cleaning and recycling.

The study will be published in the July issue of the journal Nature Cell Biology, and is now available online.

"Our studies indicate that UVRAG tumor suppressor functionally connects and manages two distinct but converged membrane traffic routes for garbage cleaning and cargo recycling," says Chengyu Liang, M.D., Ph.D., assistant professor of research in the Department of Molecular Microbiology and Immunology at the Keck School of Medicine of USC.

The study identified a novel mechanism of the UVRAG tumor suppressor in regulation of autophagy, a mechanism that enables cells to digest or turn over their own contents for maintaining homeostasis (a balanced, stable condition) and responding to various stresses.

Autophagy is marked by the assembly of specialized vesicles called autophagosomes (the cellular equivalent of garbage bags) that engulf damaged proteins, organelles and invading microbes. The "bagged garbage" is then delivered to lysosomes (the cell's garbage disposal system) through autophagic trafficking that involves autophagosome-lysosome fusion. This fusion disposes of waste with the help of lysosomal enzymes for recycling.

The findings of the study indicate that the tumor suppressor UVRAG not only facilities autophagosome formation, but also facilitates autophagosome maturation by association with the C Vps complex, a cellular machinery that facilitates membrane fusion.

In addition to identifying a novel mechanism of the UVRAG tumor suppressor in autophagy regulation, the study also identified UVRAG as an important effector protein in membrane trafficking and demonstrated the connection between endocytic and autophagic trafficking. The research conducted by Liang and colleagues with Jae U. Jung, Ph.D., professor and chair of the Department of Molecular Microbiology and Immunology at the Keck School of Medicine, suggests a functional connection and coordinated regulation of two distinct but converged membrane trafficking pathways.

"The report provides new insights into understanding some human diseases with compromised autophagic and endosomal trafficking, including cardiomyopathy (a disease of the heart muscle), myopathy (a neuromuscular disease), neuronal ceroid lipofuscinosis (genetic disorders of nerve cells) and Danon Disease )a genetic disorder characterized by heart problems)," Liang says.

The findings warrant further study into whether the UVRAG-mediated trafficking activity contributes to its tumor suppression function, she says.

Meghan Lewit | EurekAlert!
Further information:
http://www.usc.edu

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>