Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study Underway to Find an Alternative Cure for Crohn's Disease and Ulcerative Colitis

19.06.2008
Rush University Medical Center Exploring the Effectiveness of Dietary and Mind/Body Alternatives

Two research studies evaluating dietary changes and complementary medicine for the treatment of inflammatory bowel diseases (IBD) have been launched at Rush University Medical Center. Funded by the National Institute of Health, one study will look at the impact of mind/body medicine on patients suffering from ulcerative colitis (UC) and the other will assess how diet impacts patients with Crohn’s Disease.

There are two main types of IBD, Crohn’s disease and UC, which afflict approximately one million Americans. These diseases cause chronic inflammation of the intestinal tract, causing a variety of symptoms such as abdominal pain, diarrhea and rectal bleeding.

"Both Crohn’s disease and ulcerative colitis are due to an autoimmune response to the bacteria or bacterial antigens inside the intestines,” said Dr. Ali Keshavarzian, director of digestive diseases and nutrition at Rush and principal investigator and co-investigator on the studies. “Basically, the immune system is having an abnormally aggressive reaction to the bacteria."

"We want to control flare-ups of the diseases," said Keshavarzian. "Unfortunately, the treatments for IBD can be toxic and risky. There are increased risks of cancer, infection and even death as a result of IBD treatment. That’s why we’re looking at how diet as well as stress relate to the flare-ups. It may be that if we can lower stress and get the right diet, we may be able to control these illnesses."

Mind/Body Alternatives for Treating Ulcerative Colitis

One study is looking for participants suffering from UC in order to find out if complementary and alternative medicine techniques may help reduce the effects when conventional medicine has not been successful.

"We’re looking at the relationship between stress and ulcerative colitis flare-ups,” said Dr. Sharon Jedel, clinical psychologist in the section of gastroenterology at Rush and the study’s co-investigator. "The trial includes education about stress and training individuals in certain stress reduction techniques using alternative therapies."

"Approximately 40 percent of patients with IBD use complementary and alternative medicine; however, there is a lack of scientific evidence of the efficacy," said Keshavarzian. "Complementary treatments and services are a large, yet hidden section of our health care system."

Rush is looking to enroll 100 subjects suffering from moderately severe UC who have experienced a flare-up in the last six months. Participants will be assigned randomly to one of two possible eight-week courses on mind/body medicine.

Research on Diet's Effect on Crohn's Disease

The second study which is a dietary trial is looking for 90 participants with Crohn's disease to see if diet adjustments as well as dietary food supplements promoting the growth of good bacteria might help control flare ups.

"We’re trying to get improve the mix of bacteria in the intestines of patients with IBD. Imagine making a picture with different colors," said Dr. Ece A. Mutlu, gastroenterologist at Rush and principal investigator on the study. "It could be terrible or harmonious depending on the composition and quantity of certain colors. We’re trying to create a harmonious environment in the intestines with the right types of bacteria."

"One of the many advantages of coming to Rush is that we’re looking for alternatives to IBD treatment that may have less side effects," says Mutlu. "Our hope is to find a number of solutions to control these debilitating diseases."

To enroll in the dietary study for Crohn’s Disease, contact Susan L. Mikolaitis at 312-563-3892. For more information about the ulcerative colitis and stress study, contact Mary Marshall at 312-942-2845.

About Ulcerative Colitis

Ulcerative Colitis (UC) is a type of inflammatory bowel disease which affects only the innermost lining of the large intestine or colon and the rectum. It occurs in individuals of all ages, but is more common in people between the ages of 15 and 30. Additionally, Caucasians, people of Jewish heritage and those with a family history have an increased risk.

About Crohn’s Disease

Crohn’s Disease, sometimes called ileitis or enteritis, is a type of inflammatory bowel disease which can affect any area of the digestive tract, from the mouth to the anus. However, it is most common in the lower part of the small intestine called the ileum. Crohn’s Disease occurs in individuals of all ages, but it is more common in people between the ages of 20 and 30. Additionally, people of Jewish heritage and those with a family history have an increased risk.

RushUniversity Medical Center is an academic medical center that encompasses the more than 600 staffed-bed hospital (including Rush Children’s Hospital), the Johnston R. Bowman Health Center and Rush University. Rush University, with more than 1,270 students, is home to one of the first medical schools in the Midwest, and one of the nation’s top-ranked nursing colleges. Rush University also offers graduate programs in allied health and the basic sciences. Rush is noted for bringing together clinical care and research to address major health problems, including arthritis and orthopedic disorders, cancer, heart disease, mental illness, neurological disorders and diseases associated with aging.

Deb Song | EurekAlert!
Further information:
http://www.rush.edu
http://www.rush.edu/webapps/MEDREL/servlet/NewsRelease?ID=1055

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>