These are the results from a long-term study correlating life-style, immune system development and allergies, led by the Helmholtz Center for Environmental Research in Leipzig (UFZ), the Helmholtz Zentrum München and the “Institut für Umweltmedizinische Forschung” (IUF) in Duesseldorf.
The researchers had examined blood samples taken from 234 six-year old children and discovered increased blood concentrations of the stress-related peptide VIP (vasoactive intestinal polypeptide) in connection with moving house or the separation of parents.
The neuropeptide VIP could take on a mediator role between stress events in life and the regulation of immune responses, researchers write in the scientific journal Pediatric Allergy and Immunology. The fact that stress events can have an influence on the development of allergies has been known for a while. The mechanisms behind this however remained unexplained for a long time. In the study that has now been published, stress events were investigated for the first time during early childhood within a large epidemiological study using immune and stress markers.
Stress events during childhood are increasingly suspected of playing a role in the later development of asthma, allergic skin disorders, or allergic sensitisations.
Dramatic life events like the death of a family member, serious illnesses of a family member or the separation of parents, but also harmless events like for example moving house are suspected of increasing the risk of allergies for the children affected. The immune system obviously plays a mediator role between stress on the one hand and allergies on the other. Since these mechanisms had hardly been understood before, researchers attempted to identify stress-related factors showing an influence on the immune system, in the context of an epidemiological study (LISA).
At the same time as the blood tests, researchers together with colleagues from the Institute for Social Medicine at the University of Lübeck also analysed the most diverse social factors in the children’s environment, in order to find out which factors are causing stress-related regulation deficiencies of the immune system. With children, whose parents had separated over the last year, researchers found increased blood concentrations of the neuropeptide VIP (vasoactive intestinal polypeptide) as well as an increased concentration of immune markers, which are related to the occurrence of allergic reactions, like for example the cytokine IL-4. By comparison, serious diseases or the death of close relatives led to no remarkable changes. Likewise, the unemployment of parents was not associated with increased concentrations of the stress-related peptides in the children's blood.
Pediatric Allergy and Immunology 2008, Feb 25 [Epub ahead of print] doi:10.1111/j.1399-3038.2008.00727.xHerberth G, Weber A, Röder S, Krämer U, Diez U, Borte M, Lehmann I. The stress of relocation and neuropeptides: an epidemiological study in children.
Clinical Experimental Allergy 2006, 36, 1408-1416 doi:10.1111/j.1365-2222.2006.02576.xFurther information from:
The Helmholtz Association helps solve major, pressing challenges facing society, science and the economy with top scientific achievements in six research areas: Energy, Earth and Environment, Health, Key Technologies, Structure of Matter, Transport and Space. With 25,700 employees in 15 research centres and an annual budget of around EUR 2.3 billion, the Helmholtz Association is Germany's largest scientific organisation. Its work follows in the tradition of the great natural scientist Hermann von Helmholtz (1821-1894).
Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT
Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy