"Although no recommendations are available regarding the treatment of mild abnormalities of thyroid hormone levels in patients with CKD not requiring dialysis, these abnormalities could represent a risk factor for cardiovascular disease and might also be implicated in kidney disease progression," comments lead authors Dr. Michel Chonchol of University of Colorado Health Sciences Center and Dr. Giovanni Targher of University of Verona, Italy.
The researchers analyzed routine blood test results in more than 3,000 patients with CKD who were not receiving dialysis. Patients with CKD have loss of kidney function that, in many cases, progresses to end-stage renal disease (ESRD)—permanent loss of kidney function requiring dialysis or transplantation.
Overall, 9.5 percent of patients with CKD had subclinical hypothyroidism. This means reductions in thyroid hormone levels that are detected on blood tests with no abnormal signs or symptoms.The lower the patients' kidney function, the higher their risk of subclinical hypothyroidism. Seven percent of patients with mild CKD had low thyroid function, compared to 18 percent of those with moderate CKD. After adjustment for other factors, patients with moderate CKD were 73 percent more likely to have subclinical hypothyroidism.
Subclinical hypothyroidism is common, especially among older adults; lab tests show low thyroid function in four to 10 percent of the general population. Although increased rates of thyroid abnormalities have been reported in patients with ESRD, the new study is the first to show an increased rate of subclinical hypothyroidism in CKD patients not requiring chronic dialysis.
The nature and consequences of the link between CKD and low thyroid function are not yet clear. When hypothyroidism becomes more severe, it can cause reduced heart function, which can lead to progressively worsening kidney function. Thus the presence of subclinical hypothyroidism in patients with CKD might be a risk factor for both cardiovascular disease and progressive kidney disease.
Because of the lack of follow-up data, the study cannot determine whether there is any causal relationship between subclinical hypothyroidism and CKD. "Further studies should evaluate if mild elevations of the thyroid hormone are harmful for patients with kidney disease and explore the possibility of treating mild abnormalities of thyroid function with thyroid hormone replacement," according to Drs. Chonchol and Targher.
Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT
Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy