Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Understanding Cancer of the Nasopharynx

23.05.2008
Cancer of the nasopharynx has its highest incidence in South East Asia, and is more prevalent in the Chinese population. Past studies linked its development to genetic predisposition and herpesvirus infections. UNIMAS researchers in this on-going project have further discovered the involvement of genes not previously implicated.

Nasopharyngeal carcinoma (NPC) is cancer of the nasopharynx (the uppermost part of the throat that connects the back of the nose to the back of the throat). Published studies suggested genetic predisposition as well as infections by a member of the herpesvirus in the development of NPC. Investigation of both aspects is currently conducted in Universiti Malaysia Sarawak.

Globally, NPC has its highest incidence in South East Asia, and is more prevalent in the Chinese population. Comparison between mainland Chinese and Caucasian showed a 40-fold risk of NPC occurrence in the former.

In Malaysia, the Chinese population represents the highest risk group, constituting 72% of the reported cases. Like most types of cancer, however, the origin of NPC is most probably multifactorial and is specified by several genes. Indeed, other research findings had implicated several genes in NPC tumour progression.

To this date, there are no published studies to correlate the functions, activities and interactions among these genes with regards to the development of NPC. The hypothesis therefore is that there are significant relationships and interactions among these known susceptibility genes (and others?) and their physiological targets in the predisposition and development of NPC.

As the occurrence of NPC is ethnically biased, the genetic background of the susceptible race group probably plays an important role in their predisposition. The question is, what are the genetic markers responsible for these high-risk groups and what are the underlying mechanism(s) of these genetic markers in the predisposition and development of NPC.

On the other hand, Epstein-Barr Virus (EBV) association with NPC has been reported extensively. The tight association indicates a role for EBV in the development of NPC but the mechanism remains unknown, though chromosome rearrangements (specific genetic sequence rearrangements) have been widely detected in NPC cases. While EBV infection and chromosomal rearrangements are commonly observed in NPC, there is no published study looking into their relationship in terms of NPC development.

To unravel the mechanism leading to NPC, a research group in UNIMAS has narrowed their target on the activity of some genes and discovered the involvement of genes that had not been implicated before. The group is also looking at the role of EBV-induced apoptosis in chromosome rearrangements in NPC and their current findings have put support to their hypothesis, qualifying further investigation into other regions of chromosome rearrangements.

It is hoped that the combine outcomes of both studies will give more insight and information to the field of NPC research.

Resni Mona | ResearchSEA
Further information:
http://www.unimas.my

More articles from Studies and Analyses:

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Disarray in the brain
18.12.2017 | Universität zu Lübeck

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Optical Nanoscope Allows Imaging of Quantum Dots

Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.

Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Rutgers scientists discover 'Legos of life'

23.01.2018 | Life Sciences

Seabed mining could destroy ecosystems

23.01.2018 | Earth Sciences

Transportable laser

23.01.2018 | Physics and Astronomy

VideoLinks Science & Research
Overview of more VideoLinks >>>