Nasopharyngeal carcinoma (NPC) is cancer of the nasopharynx (the uppermost part of the throat that connects the back of the nose to the back of the throat). Published studies suggested genetic predisposition as well as infections by a member of the herpesvirus in the development of NPC. Investigation of both aspects is currently conducted in Universiti Malaysia Sarawak.
Globally, NPC has its highest incidence in South East Asia, and is more prevalent in the Chinese population. Comparison between mainland Chinese and Caucasian showed a 40-fold risk of NPC occurrence in the former.
In Malaysia, the Chinese population represents the highest risk group, constituting 72% of the reported cases. Like most types of cancer, however, the origin of NPC is most probably multifactorial and is specified by several genes. Indeed, other research findings had implicated several genes in NPC tumour progression.
To this date, there are no published studies to correlate the functions, activities and interactions among these genes with regards to the development of NPC. The hypothesis therefore is that there are significant relationships and interactions among these known susceptibility genes (and others?) and their physiological targets in the predisposition and development of NPC.
As the occurrence of NPC is ethnically biased, the genetic background of the susceptible race group probably plays an important role in their predisposition. The question is, what are the genetic markers responsible for these high-risk groups and what are the underlying mechanism(s) of these genetic markers in the predisposition and development of NPC.
On the other hand, Epstein-Barr Virus (EBV) association with NPC has been reported extensively. The tight association indicates a role for EBV in the development of NPC but the mechanism remains unknown, though chromosome rearrangements (specific genetic sequence rearrangements) have been widely detected in NPC cases. While EBV infection and chromosomal rearrangements are commonly observed in NPC, there is no published study looking into their relationship in terms of NPC development.
To unravel the mechanism leading to NPC, a research group in UNIMAS has narrowed their target on the activity of some genes and discovered the involvement of genes that had not been implicated before. The group is also looking at the role of EBV-induced apoptosis in chromosome rearrangements in NPC and their current findings have put support to their hypothesis, qualifying further investigation into other regions of chromosome rearrangements.
It is hoped that the combine outcomes of both studies will give more insight and information to the field of NPC research.
Resni Mona | ResearchSEA
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
Scientists have developed a new method of characterizing graphene’s properties without applying disruptive electrical contacts, allowing them to investigate both the resistance and quantum capacitance of graphene and other two-dimensional materials. Researchers from the Swiss Nanoscience Institute and the University of Basel’s Department of Physics reported their findings in the journal Physical Review Applied.
Graphene consists of a single layer of carbon atoms. It is transparent, harder than diamond and stronger than steel, yet flexible, and a significantly better...
The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
30.05.2017 | Life Sciences
30.05.2017 | Life Sciences
30.05.2017 | Physics and Astronomy