Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Analysis: Control Reduces Cardiovascular Risk by 42%

Results of a new analysis of the Treating to New Targets (TNT) study show that intensive low-density lipoprotein (LDL) cholesterol-lowering in patients with stable coronary heart disease (CHD) whose systolic blood pressure was less than 140 mmHg reduced the risk of major cardiovascular events, including heart attack, stroke and resuscitated cardiac arrest, by 42 percent compared with less intensive LDL lowering and uncontrolled blood pressure of 140 mmHg or higher.

Led by John B. Kostis, MD, the John G. Detwiler professor of cardiology, professor of medicine and chair, department of medicine, UMDNJ-Robert Wood Johnson Medical School, this post-hoc analysis of the five-year 10,001 patient TNT study that was funded by Pfizer, Inc., was published in the May 2008 issue of the Journal of Clinical Hypertension.

“People who have both high cholesterol and high blood pressure are at greater risk for cardiovascular disease than those with either condition alone.Yet, a minority of patients with both conditions is treated to currently recommended targets. In one study less than a third of such patients were treated and only one in ten were treated to target,” said Dr. Kostis. “The analysis reported today reminds us that intensive management of both cholesterol and blood pressure, can significantly reduce the risk of heart attacks and strokes.”

Among the 10,001 patients of TNT, 9,739 who had both LDL cholesterol and systolic blood pressure measured at three months after randomization, were included in this analysis. All patients received cholesterol-lowering therapy with atorvastatin calcium (Lipitor®) 80 mg or 10 mg. More than 95 percent of patients in this analysis also were receiving antihypertensive therapy.

As reported in the published analysis, patients were divided into groups based on LDL levels (73 mg/dL and lower; 74 to 94 mg/dL; or 95 mg/dL and higher) and systolic blood pressure (140 mmHg and higher, or lower than 140 mmHg) at three months. During a median follow-up of 4.9 years, patients with the lowest LDL and the lowest BP had the lowest risk of major cardiovascular events. For each of the three LDL groups, the rate of cardiovascular events was lower in patients whose systolic blood pressure (SBP) was below 140 mmHg. The benefit of SBP

“Overall, this study provides new evidence of the importance of controlling both dyslipidemia and hypertension” said Dr. Kostis. “However, controlling other risk factors, especially smoking, is still essential to reducing the risk of heart attack and stroke.”

To interview Dr. Kostis, contact Jennifer Forbes at or 732-235-6356.

About Robert Wood Johnson Medical School:
As one of the nation’s leading comprehensive medical schools, UMDNJ-Robert Wood Johnson Medical School is dedicated to the pursuit of excellence in education, research, health care delivery, and the promotion of community health. In cooperation with Robert Wood Johnson University Hospital, the medical school’s principal affiliate, they comprise New Jersey’s premier academic medical center. In addition, Robert Wood Johnson Medical School has 34 other hospital affiliates and ambulatory care sites throughout the region.

As one of the eight schools of the University of Medicine and Dentistry of New Jersey with 2,500 full-time and volunteer faculty, Robert Wood Johnson Medical School encompasses 22 basic science and clinical departments, hosts centers and institutes including The Cancer Institute of New Jersey, the Child Health Institute of New Jersey, the Center for Advanced Biotechnology and Medicine, the Environmental and Occupational Health Sciences Institute, and the Stem Cell Institute of New Jersey. The medical school maintains educational programs at the undergraduate, graduate and postgraduate levels for more than 1,500 students on its campuses in New Brunswick, Piscataway, and Camden, and provides continuing education courses for health care professionals and community education programs.

Jennifer Forbes | newswise
Further information:

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

Im Focus: Tiny implants for cells are functional in vivo

For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.

In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

Latest News

Physicists made crystal lattice from polaritons

20.03.2018 | Physics and Astronomy

Mars' oceans formed early, possibly aided by massive volcanic eruptions

20.03.2018 | Physics and Astronomy

Thawing permafrost produces more methane than expected

20.03.2018 | Earth Sciences

Science & Research
Overview of more VideoLinks >>>