Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research findings enable more reliable prognoses for breast cancer

15.05.2008
Researchers at Umeå University in Sweden have shown that the length of telomeres in blood cells in newly diagnosed breast cancer patients is tied to survival rates. The study, published in the journal Cancer Research, was carried out by a research team headed by Professor Göran Roos at the Department of Medical Bioscience, Pathology.

The study shows that the telomere length in blood cells is associated with prognosis for breast cancer. The blood cells of the cancer patients in the study had somewhat longer telomeres than those of controls. It is interesting to note that within the tumor group patients with longer telomeres (= longer than the mean length of telomeres) had a significantly poorer prognosis than did patients with shorter telomeres. This difference in survival was above all seen in patients with more advanced disease, that is, with larger tumors and metastases in local lymph glands.

It is particularly important that the telomere length in these blood cells proved to be a prognostic marker that is independent of other well-known prognostic markers (tumor size, tumor metastasis). In other words, this new biological marker appears to be able to tell us more about the future prospects of cancer patients than previously known markers can.

The tips of chromosomes, telomeres, are important for the genetic stability of our cells. In normal cells, telomeres are shortened each time cells divide, whereas cancer cells usually have stable telomere length. This stability helps provide cancer cells with eternal life. The length of a cell's telomeres is determined by the balance of positive and negative factors, many of which are unknown.

Just why breast cancer patients with longer telomeres in normal blood cells have poorer prognoses than other patients is unclear at present. A number of explanations are under discussion. One probable hypothesis is that patients' telomere lengths are a reflection of presently unknown functions of the immune defense system. Preliminary unpublished data from the research team show that this biological marker can provide prognostic information for other tumor diseases as well. This makes it even more important to understand the mechanisms behind the observed differences in telomere length.

The study was performed in collaboration with colleagues at the oncology and medical clinics at Norrland University Hospital and Malmö Academic Hospital. The study comprises 265 patients who gave blood samples directly after they were diagnoses with breast cancer and 446 controls.

For more information, please contact Professor Göran Roos, Department of Medical Bioscience, Pathology, phone: +46 (0)90-785 18 01; cell phone: +46 (0)70-630 86 92; or e-mail goran.roos@medbio.umu.se.

Pressofficer Bertil Born; +46-090 786 60 58;bertil.born@adm.umu.se;

Reference:
Svenson U, Nordfjäll K, Stegmayr B, Manjer J, Nilsson P, Tavelin B, Henriksson R, Lenner P, Roos G. Breast cancer survival is associated with telomere length in peripheral blood cells. Cancer Research 2008, published May 15.

Bertil Born | idw
Further information:
http://cancerres.aacrjournals.org/future/68.10.shtml
http://www.vr.se

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>