Deficits in gamma-aminobutyric acid (GABA) neuronal populations are being linked to a growing number of psychiatric disorders, including schizophrenia.
The researchers in this study have used an animal model to study the role of the neocortex, a part of the brain responsible for motor activity, in hyperactive behavior.
Müller Smith and colleagues demonstrate that mice lacking the fibroblast growth factor receptor 1 (FGFR1) display profound, non-habituating hyperactivity that is correlated with a lack of parvalbumin-positive and somatostatin-positive inhibitory interneurons in the neocortex.
A decreased number of these same interneurons is “one of the most consistent findings in schizophrenia and psychotic disorders,” explains Dr. Flora Vaccarino, corresponding author for this article.
Dr. Vaccarino adds, “Interestingly, the loss of parvalbumin+ cells was inversely proportional to locomotor hyperactivity in these animals.”
Although the authors do not know yet know the mechanism by which this occurs, she notes that “these mice can be used a model for developing treatments that may reverse this deficit.”
Jayne Dawkins | alfa
Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena
Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
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The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
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Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
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