Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lack of motivation in schizophrenia linked to brain chemical imbalance

08.05.2008
A study of patients with psychotic illnesses such as schizophrenia suggests an alternative explanation for why many sufferers lack motivation. The research is described today in BioMed Central’s journal BMC Psychiatry.

In addition to the hallucinations that often characterize schizophrenia, patients also have major problems with apathy and lack of motivation. The dopamine hypothesis argues that unusual behaviour associated with schizophrenia can largely be explained by variations in the dopamine function of the brain.

Exploring a possible link between dopamine activity and the lack of motivation could be key to developing new approaches to helping such patients cope with life.

In a study funded by the National Institute of Health Research, Dr Graham Murray of the Department of Psychiatry at the University of Cambridge and colleagues studied 18 patients presenting with first-episode psychotic symptoms. They compared the patients' performance against 19 healthy participants in a computerised test of motivated behaviour.

The participants took part in a reaction time test, assigning a reward to each trial. In the control group, almost all individuals reacted faster if the potential reward for completing the task was higher. This well documented phenomenon was observed in less than a quarter of the first-episode psychosis group, suggesting an abnormality in the processing of incentives for their actions. Eleven of these participants were taking atypical antipsychotic medications, which are sometimes thought to be responsible for ‘demotivating’ patients. However, this study found that these medications had no significant effect on the results.

In the past, some critics have suggested that patients’ motivational problems are simply secondary to long-term treatment effects, or institutionalisation, but because the researchers studied young adults at the very early stages of their illness, they could rule out this possibility. "Patients with psychosis already have motivational deficits the first time they present to health services." said Dr Murray. ”Understanding the brain basis of these problems will ultimately help in developing new treatments.”

The next step in demonstrating a link between lack of motivation and the brain's biochemical reward system will be to investigate whether self-motivation can be safely stimulated in patients with psychoses using medication, including drugs that trigger the release of dopamine but which do not worsen their other symptoms.

Charlotte Webber | alfa
Further information:
http://www.biomedcentral.com
http://www.biomedcentral.com/bmcpsychiatry/

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>