Several studies have shown that early life environment plays an important role in susceptibility to chronic disease later in life. “Body measures such as knee height and arm span are often used as biological indicators of early life deficits, such as a lack of nutrients,” said Tina L. Huang, PhD, who was with Johns Hopkins University in Baltimore, MD, when the study started.
Huang is now with the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston, MA. “Because the development of the brain region most severely affected by Alzheimer’s disease coincides with the greatest change in limb length, we thought it was possible that men and women with shorter limbs could be at greater risk for developing dementia and Alzheimer’s disease.”
Researchers from the Cardiovascular Health Cognition Study followed 2,798 people for an average of five years and took knee height and arm span measurements. Most participants were white with an average age of 72. By the end of the study, 480 developed dementia.
Researchers found women with the shortest arm spans were 1.5 times more likely to develop dementia and Alzheimer’s disease than women with longer arm spans. For every inch longer a woman’s leg, the risk of dementia and Alzheimer’s disease was reduced by 16 percent.
In men, only arm span was associated with a lower risk of dementia. With every increased inch in arm span, men had a six-percent increase in risk of dementia. The associations with such measures in men and women were stronger toward Alzheimer’s disease compared to other types of dementia.
Huang says there is a strong correlation between height and socioeconomic background, and trends are reflected as early as the first two years of life. “Reduced height for age, or stunting, is thought to be most closely tied to environment and the quality of diet in early life, which corresponds with periods of the fastest leg growth,” said Huang. “As a result, environment in the first years of life may play an important role in determining future dementia risk.”
“Our findings are consistent with other studies that have been done in Korean populations, where shorter limb length was associated with greater risk of dementia,” said Huang.
The study was supported by grants from the National Institute on Aging, the National Heart, Lung and Blood Institute and the National Institutes of Health.
The American Academy of Neurology, an association of more than 21,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease, and multiple sclerosis.
Angela Babb | American Academy of Neurology
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology