Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Major discovery in the treatment of aortic valve stenosis

22.04.2008
Experimental study on most common form of heart valve disease in Western countries may lead to new treatments

A team of scientists from the Université de Montréal and the Montreal Heart Institute Research Centre, led by Dr. Jean-Claude Tardif, has completed an important study that show how a new type of medication can lead to an improvement in the aortic valve narrowing.

This type of treatment based on raising high-density lipoproteins (HDL), the so-called good cholesterol level in patients suffering from aortic valve stenosis, could potentially transform the treatment approach of this disease, notably by avoiding open heart surgery. Study results have been published on-line in the British Journal of Pharmacology.

Renewed hope for patients

“We are delighted to see that the new type of drug used, based on HDL, led to the regression of the aortic valve stenosis in an experimental model,” underlined Dr. Jean-Claude Tardif, director of the Montreal Heart Institute Research Centre and professor of medicine at the Montreal Heart Institute and the Université de Montréal.

“This important discovery warrants further clinical studies on patients suffering from this frequent disease. This new medical option could possibly provide us with an alternative to the cardiac surgery of aortic valve replacement.”

What is aortic valve stenosis?

Aortic valve stenosis is the most common form of heart valve disease in Western countries. In Canada, it could affect some 150,000 persons. The disease is characterized by a narrowing of the aortic valve opening, causing a difference in blood pressure between the heart and the rest of the body, which is particularly dangerous for the patient.

The main symptoms of severe aortic valve stenosis are exercise intolerance, angina and syncope (fainting). Its frequency in the population aged over 65 is two percent to four percent. Its major complications are, in addition to the need for cardiac surgery, heart failure and sudden death. The disease therefore represents a major health problem with dramatic consequences if replacement surgery is not performed in time. In the United States, about 50,000 patients a year must undergo aortic valve replacement surgery.

Details on the study

The study was conducted on animals fed a diet rich in cholesterol until aortic valve stenosis was detected by echocardiography, the medical imaging ultrasound system used for humans. The animals were then divided into two groups: a control group given injections of a neutral solution, and a group treated for two weeks with injections of a drug based on raising the “good cholesterol” (ApoA-I mimetic peptide).

The findings were particularly interesting, since after only 14 days of treatment, the aortic valve opening in subjects had returned again to almost normal in the treated group, whereas it had improved by a mere 13 percent by eliminating the high-fat diet in the control group.

What’s more, the thickness of the aortic valve decreased by 21 percent in the treated group, while remaining unchanged in the control group.Microscopic analysis revealed that valve lesions were significantly less extensive in the treatment group than in the control group. The treatment also reduced aortic valve calcifications.

Doris Prince | EurekAlert!
Further information:
http://www.icm-mhi.org
http://www.umontreal.ca/english/index.htm

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>