“We were interested in finding out just how effective mammography and sonography were, when used together, in excluding breast cancer in women with palpable findings,” said Erica Tyler, MD, lead author of the study. “Our study differs from others because after enrollment, we followed patients for at least 3 years to see if any of the palpable lumps later were diagnosed as malignant,” she said.
The study evaluated 414 palpable breast lesions using both mammography and sonography. Imaging of 167 lesions was negative, with normal appearing breast tissue in the area of clinical concern and no mammographic or sonographic findings to explain the palpable finding. Among the 167 women with negative mammography and sonography, 120 reached a diagnostic endpoint with 28 patients undergoing a biopsy that showed no malignancy and 92 patients showing no malignancy after follow-up of at least 36 months. There were 118 true-negative and two false-negative cases said Dr. Tyler. The NPV when using mammography and sonography together was 98%, she said.
The study showed that both false-negative lesions “became increasingly suspicious on clinical exam and later became apparent by imaging,” said Dr. Tyler. One false-negative lesion occurred in a patient with heterogeneously dense tissue and was diagnosed 74 months after initial clinical discovery. The second false-negative lesion occurred in extremely dense tissue and was diagnosed 81 months after initial discovery.
“Our findings support those reported in other studies. Uncommonly, palpable malignancies may not be detectable on both mammography and sonography, and this combination of imaging doesn’t rule out malignancy,” said Dr. Tyler. “Also, based on our findings, long term clinical and imaging follow-up of over five years may be needed to diagnose all palpable cancers, when the initial mammogram and sonogram are unrevealing,” she said.
Necoya Tyson | EurekAlert!
Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Earth Sciences
24.02.2017 | Agricultural and Forestry Science
24.02.2017 | Life Sciences