These are the main findings of a study on grafting of new neurons to the brain in patients with Parkinson’s disease. The study, headed by a team of researchers from Lund University in collaboration with London scientists, has been published in a recent issue of Nature Medicine.
'Previous studies have shown that transplanted dopamine cells can clearly improve speed of movement, reduce rigidity and the need for medication for at least a decade', says Jia-Yi Li, Associate Professor of Neurobiology, Neuronal Survival Unit at Lund University. 'We now see that they also are alive in large numbers, which is very exciting.'
However, in addition to the long-term survival of transplanted neurons, the scientists also found that Parkinson’s disease changes may appear inside a graft. This suggests that the disease mechanism is able to transfer gradually from a sick to a healthy cell in the brain.
'Our results suggest that key features of Parkinson's disease pathology slowly transfer from the patient’s brains to the healthy nerve cells in the transplant', says Patrik Brundin, Professor of Neuroscience and Head of the Neuronal Survival Unit at Lund University.
'We still do not know the precise cellular mechanisms, but the findings open up new exciting lines of research. If we can crack the mechanism, we may be able to devise treatments that prevent or slow disease progression in the future.'
The research group at Lund University and Lund University Hospital has earlier shown that the transplanted cells are functional for a decade. The new findings, that extend the survival time even further, mean that cell therapy is still a viable possibility.
'Although we have now found that the grafted cells may be affected by the disease, the pathological changes appear late. In my view transplantation of dopamine cells, probably generated from stem cells, therefore remains a promising and important novel strategy for the treatment of patients with Parkinson’s disease', says Olle Lindvall, Professor of Neurology at Lund University Hospital.
Ingela Bjoerck | alfa
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences