Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Parkinson transplants survive at least 16 years

09.04.2008
Transplanted cells can survive in the brain for over one and half decade. However, some of the transplanted cells developed Parkinson-like features which is very surprising.

These are the main findings of a study on grafting of new neurons to the brain in patients with Parkinson’s disease. The study, headed by a team of researchers from Lund University in collaboration with London scientists, has been published in a recent issue of Nature Medicine.

'Previous studies have shown that transplanted dopamine cells can clearly improve speed of movement, reduce rigidity and the need for medication for at least a decade', says Jia-Yi Li, Associate Professor of Neurobiology, Neuronal Survival Unit at Lund University. 'We now see that they also are alive in large numbers, which is very exciting.'

However, in addition to the long-term survival of transplanted neurons, the scientists also found that Parkinson’s disease changes may appear inside a graft. This suggests that the disease mechanism is able to transfer gradually from a sick to a healthy cell in the brain.

'Our results suggest that key features of Parkinson's disease pathology slowly transfer from the patient’s brains to the healthy nerve cells in the transplant', says Patrik Brundin, Professor of Neuroscience and Head of the Neuronal Survival Unit at Lund University.

'We still do not know the precise cellular mechanisms, but the findings open up new exciting lines of research. If we can crack the mechanism, we may be able to devise treatments that prevent or slow disease progression in the future.'

The research group at Lund University and Lund University Hospital has earlier shown that the transplanted cells are functional for a decade. The new findings, that extend the survival time even further, mean that cell therapy is still a viable possibility.

'Although we have now found that the grafted cells may be affected by the disease, the pathological changes appear late. In my view transplantation of dopamine cells, probably generated from stem cells, therefore remains a promising and important novel strategy for the treatment of patients with Parkinson’s disease', says Olle Lindvall, Professor of Neurology at Lund University Hospital.

Ingela Bjoerck | alfa
Further information:
http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm1746.html
http://www.lu.se

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Contacting the molecular world through graphene nanoribbons

19.02.2018 | Materials Sciences

When Proteins Shake Hands

19.02.2018 | Materials Sciences

Cells communicate in a dynamic code

19.02.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>