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Study paves way for development of macular degeneration cures

Animal model partially funded by the Foundation Fighting Blindness developed at Cleveland Clinic, published in Nature Medicine

A new study of age-related macular degeneration (AMD), a disease that affects more than nine million Americans, will pave the way for the biopharmaceutical industry to develop better treatments and cures, according to the Foundation Fighting Blindness, which partially funded the research.

“This is the first time that scientists have been able to create an AMD animal model that closely represents the disease in people,” said Stephen Rose, Ph.D., Chief Research Officer, Foundation Fighting Blindness. “Though there are some treatments for the wet form of AMD, we still don’t have a cure for the condition, and millions of people are still at risk of losing their vision to both the dry and wet forms. This new model will greatly enhance the development of better treatments and potentially a cure.”

Researchers at the Cleveland Clinic Lerner College of Medicine used oxidative chemicals to sensitize the immune systems in mice and create AMD . The study is titled “Oxidative damage-induced inflammation initiates age-related macular degeneration,” and was published in the online edition of the scientific journal Nature Medicine on January 27.

Once developed, therapies for the dry form, or early stage of AMD, could be implemented before vision is lost, which would be a dramatic breakthrough in the treatment of the disease, Rose said.

David Harrison | EurekAlert!
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