The study shows the safety of delivering three drugs simultaneously – ivermectin, albendazole and praziquantel – in order to tackle three diseases, elephantiasis (lymphatic filariasis), soil-transmitted worms (helminths), and schistosomiasis. Public health interventions based on distribution of these drugs have generally been implemented using one drug at a time. But a coordinated approach could prove to be much more resource- and cost-effective.
“Only through integration will we reduce distribution costs, make the best use of our available human resources and increase community participation and compliance, without any added risk to the population,” said study author Khalfan A. Mohammed, Manager of the new Zanzibar Integrated Helminth Control Programme of the Ministry of Health and Social Welfare.
The study, initiated by the WHO in cooperation with the Ministry of Health and Social Welfare of Zanzibar, United Republic of Tanzania, and the Liverpool School of Tropical Medicine’s Lymphatic Filariasis Support Centre, examined the possible side-effects of a triple-drug administration in Zanzibar, United Republic of Tanzania, where several previous treatment rounds with one or two drugs had already taken place.
First, a total of 5055 Zanzibari children and adults living in areas endemic for lymphatic filariasis, soil-transmitted helminthiasis (STH), and schistosomiasis were enrolled in a pilot study. After finding there were no severe adverse events associated with the combined triple-therapy treatment, the researchers scaled up the intervention to make it country wide, treating the entire eligible population of over 700,000 individuals.
Surveillance carried out during both intervention periods showed that the side-effects attributable to the co-delivery of the three drugs were mild and required no medical attention. The data suggest that co-administration of the three drugs is safe in areas where LF, STH and schistosomiasis are co-endemic and populations have received repeated treatments previously.
Although WHO has long recommended the coordinated delivery of drugs to tackle neglected tropical diseases, the maximum number of drugs for simultaneous delivery was limited to two for safety reasons. If the safety of the co-administration of three drugs is confirmed by further studies, WHO is likely to include triple drug administration in its guidelines where appropriate.
“These infections compromise the lives of millions of people,” said Dr Lorenzo Savioli, co-author of the study and Director of the WHO Department of Control of Neglected Tropical Diseases. “This study is a welcome new addition to our existing arsenal of robust, low-cost and effective interventions.”
Professor David H. Molyneux of the Lymphatic Filariasis Support Centre based at the Liverpool School of Tropical Medicine, another co-author of the study, said: “The study shows that we can now offer the appropriate combination of drugs for each combination of helminthic diseases. It also shows the real advantage of working in partnership to generate practical results on the ground.”
The Honourable Sultan M. Mugheiry, Minister of Health and Social Welfare of Zanzibar, who was not a study author, commented: “Zanzibar has been on the frontline of the fight against schistosomiasis, STH and lymphatic filariasis in Africa. We hope these results will help our country but also simplify the treatment for millions of other infected individuals in the poorest parts of the developing world.”
Andrew Hyde | alfa
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg
Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
23.03.2018 | Event News
19.03.2018 | Event News
16.03.2018 | Event News
23.03.2018 | Materials Sciences
23.03.2018 | Agricultural and Forestry Science
23.03.2018 | Physics and Astronomy