Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Bacterial Infections in Premature Babies More Common Than Previously Realized

Study Shows One in Four Born with Fetal Bacteremia

Premature babies are subject to a host of threats that can result in fetal/neonatal disease. In a study published in the January 2008 issue of the American Journal of Obstetrics & Gynecology, researchers from the University of Alabama–Birmingham Medical School and the Drexel University College of Medicine found that genital mycoplasmas are a frequent cause of congenital fetal infection. 23% of neonates born between 23 and 32 weeks of gestation have positive umbilical blood cultures for two genital mycoplasmas (bacteria lacking cell walls): Ureaplasma urealyticum and Mycoplasma hominis.

Although Ureaplasma urealyticum and Mycoplasma hominis are found in 80% of vaginal and cervical fluids, infants are not generally screened for these bacterial infections. The finding that about one-quarter of early preterm infants is already infected at birth is important in reducing adverse outcomes. These newborns had a higher incidence of neonatal systemic inflammatory response syndrome (SIRS), higher incidence of bronchopulmonary dysplasia (BPD), higher serum concentrations of interleukin (IL)-6 and more evidence of placental inflammation than those with negative cultures. The earlier the gestational age at delivery, the higher the rate of a positive umbilical cord blood culture.

The data, derived from the Alabama Preterm Birth Study, included 457 consecutive singleton deliveries of infants born at 23-32 weeks’ gestation from 1996 to 2001. This study focuses on a subset of 351 women/infant pairs in the population who had umbilical cord blood cultures for U. urealyticum and M. hominis.

Writing in the article, Robert Goldenberg, M.D., Professor, Department of Obstetrics and Gynecology, Drexel University College of Medicine, states, “Given the frequency of these infections and their association with SIRS and likely with BPD, it seems reasonable to determine if infants in these categories would benefit from routine culture for Ureaplasma urealyticum and/or Mycoplasma hominis and subsequent treatment with an antibiotic effective against these organisms. Similarly, we question whether treatment of women likely to deliver an early gestational age infant with an antibiotic effective against these organisms might reduce subsequent neonatal morbidity and mortality.”’

In an accompanying editorial, Roberto Romero, MD, Chief of the Perinatology Research Branch and Program Director for Obstetrics and Perinatology at NICHD/NIH; Professor of Molecular Obstetrics and Genetics, Center of Molecular Medicine, Wayne State University, and Thomas J. Garite, MD, Professor Emeritus, Department of Obstetrics and Gynecology, University of California, Irvine, comment that the article “provides compelling evidence that congenital fetal infection is more frequent than previously realized. The detection of genital mycoplasmas is not part of routine clinical practice in obstetrics and neonatology. Similarly, standard treatment for suspected neonatal sepsis does not include antibiotics effective against these microorganisms.”

Romero and Garite further state that, “The initial uncertainties of whether genital mycoplasmas can cause fetal/neonatal disease are disappearing in light of the accumulating evidence that these microorganisms have been implicated in neonatal sepsis, pneumonia, meningitis and brain damage. Moreover, colonization of the neonatal respiratory tract with these organisms is a risk factor for chronic lung disease.”

The article is “The Alabama Preterm Birth Study: Umbilical Cord Blood Ureaplasma urealyticum and Mycoplasma hominis Cultures in Very Preterm Newborns” by Robert L Goldenberg, MD; William W Andrews, Ph.D., MD; Alice R Goepfert, MD; Ona Faye-Petersen, MD; Suzanne P Cliver; Waldemar A Carlo, MD; and John C Hauth, MD. The editorial is “Twenty Percent of Very Preterm Neonates (23 to 32 weeks) are Born with Bacteremia due to Genital Mycoplasmas” by Roberto Romero and Thomas J. Garite. Both appear in the American Journal of Obstetrics & Gynecology, Volume 198, Issue 1 (January 2008) published by Elsevier.

Pamela Poppalardo | alfa
Further information:

More articles from Studies and Analyses:

nachricht Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung

nachricht High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Greater Range and Longer Lifetime

26.10.2016 | Power and Electrical Engineering

VDI presents International Bionic Award of the Schauenburg Foundation

26.10.2016 | Awards Funding

3-D-printed magnets

26.10.2016 | Power and Electrical Engineering

More VideoLinks >>>