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Rate of Follow-Up Surgeries After Partial Mastectomy Varies Greatly

Findings could affect both cancer recurrence and overall survival rates

A new study reveals substantial differences – by both surgeon and institution – in the rates of follow-up surgeries for women who underwent a partial mastectomy for treatment of breast cancer.

Those differences, which cannot be explained by a patient’s medical or treatment history, could affect both cancer recurrence and overall survival rates, according to the study led by Laurence McCahill, M.D. of Van Andel Research Institute, Michigan State University’s College of Human Medicine, and the Richard J. Lacks Cancer Center.

The research appears in the Feb. 1 edition of the Journal of the American Medical Association.

“A partial mastectomy is one of the most commonly performed cancer operations in the United States,” said McCahill. “Currently, there are no readily identifiable quality measures that allow for meaningful comparisons of breast cancer surgical outcomes among surgeons and hospitals.

“But the current U.S. health care environment calls for increasing accountability for physicians and hospitals as well as transparency of treatment results.”

About three-fourths of women battling breast cancer have a partial mastectomy, and nearly one in four of them at some point have another surgery (re-excision) to remove additional tissue. A partial mastectomy intends to remove cancerous cells while maintaining maximum cosmetic appearance of the breast, but failure to remove all the cells at the initial operation requires additional surgery.

The additional operations can produce considerable psychological, physical and economic stress for patients and delay use of recommended supplemental therapies, according to the study, which measured variation in re-excision rates across hospitals and surgeons from 2003 to 2008. The study included more than 2,200 women with invasive breast cancer from four sites across the country.

The results show rates of re-excision varied widely and were not tied to any discernible characteristics for the patient. The study highlights the value of multicenter observational studies to pinpoint the variability in health care across different regions and health systems, McCahill said.

“While the long-term effect of this variability is beyond the scope of our study, it is feasible that cancer recurrence and overall survival could be affected by differences in initial surgical care,” he said. “The wide level of unexplained clinical variation itself represents a potential barrier to high-quality and cost-effective care of patients with breast cancer.”

The study was funded by a $1.1 million National Institutes of Health grant to Van Andel Research Institute via the American Recovery and Reinvestment Act of 2009. The two-year project led by Dr. McCahill was entitled "Improving Breast Cancer Surgery Quality through a Collaborative Surgery Database."

Media note: There will be multimedia content available, including the JAMA Report video, embedded and downloadable video, audio files, text, documents, and related links. This content will be available at 4 p.m. EST Jan. 31 at this link.

Michigan State University

Michigan State University has been working to advance the common good in uncommon ways for more than 150 years. One of the top research universities in the world, MSU focuses its vast resources on creating solutions to some of the world’s most pressing challenges, while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

For MSU news on the Web, go to Follow MSU News on Twitter at

Contact: Jason Cody, University Relations: (517) 432-0924, cell (734) 755-0210,

Saint Mary’s Health Care

Saint Mary’s Health Care, a member of the new Mercy Health, is an integrated network of health care excellence offering a unique combination of capabilities to deliver a health care experience that is more complete and personally satisfying. Our commitment to offer the latest technology and most highly skilled physicians in a holistic, patient-centered environment has made us a progressive leader in cancer care, neuroscience, orthopedics, diabetes and endocrine care, kidney transplants, and integrative medicine.

The network encompasses more than 2,500 employees, a 336-bed, JCAHO-accredited teaching hospital, The Lacks Cancer Center, the area’s only dedicated cancer hospital, Saint Mary’s Southwest, The Wege Center for Health and Learning, the Diabetes and Endocrine Center, the Hauenstein Neuroscience Center housing the area’s most comprehensive neuroscience program and state-of-the-art Emergency and Trauma services, three fitness centers, five community outreach centers and affiliations with home health care, rehabilitation services, and the area's premier primary care network, Advantage Health Physician Network. Saint Mary’s is a member of Trinity Health, the country’s fourth-largest Catholic health care system.

To contact Laurence E. McCahill, M.D., call Micki Benz, Vice President, Communications, Saint Mary's Health Care, Grand Rapids MI. 616.685.1890

Van Andel Institute

Established by Jay and Betty Van Andel in 1996, Van Andel Institute (VAI) is an independent research and educational organization based in Grand Rapids, Mich., dedicated to preserving, enhancing and expanding the frontiers of medical science, and to achieving excellence in education by probing fundamental issues of education and the learning process. VARI, the research arm of VAI, is dedicated to probing the genetic, cellular and molecular origins of cancer, Parkinson and other diseases and working to translate those findings into effective therapies. This is accomplished through the work of over 200 researchers in 18 on-site laboratories and in collaborative partnerships that span the globe. VARI is affiliated with the Translational Genomics Research Institute, (TGen), of Phoenix, Arizona.

Joe Gavan | EurekAlert!
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