There is specifically an increased risk of hip fracture after 5 years of continuous exposure and an increased risk of any fracture after 7 years continuous exposure. Short-term exposure did not appear to increase risk of fractures.
Proton pump inhibitors — a class of drugs commonly prescribed to control and prevent symptoms and complications of peptic ulcer disease and GERD (reflux) — are widely used by patients for many years.
The study looked at people aged 50 and older who had hip, spinal, or wrist fractures and were matched by a control group with no history of hip, spinal or wrist fractures.
The use of proton pump inhibitors has increased in recent years and use is often of indefinite duration.
"These factors may promote the long-term use of proton pump inhibitors, leaving patients at increased risk of osteoporosis-related fractures," write Dr. Laura Targownik and coauthors.
In a related commentary, http://www.cmaj.ca/press/pg306.pdf, Drs. Brent Richards and David Goltzman comment that three large administrative database studies have found proton pump inhibitors increase fracture risk. They caution that both the physician and patient should together weigh the risks and benefits of the long-term use of these drugs.
Monique Shaw | EurekAlert!
Do microplastics harbour additional risks by colonization with harmful bacteria?
05.04.2018 | Leibniz-Institut für Ostseeforschung Warnemünde
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy