Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein plays a critical role in the development of aggressive breast cancer

21.04.2010
New study shows dramatic difference in incidence of tumor formation based on presence of NEDD9

Researchers at Fox Chase Cancer Center have identified a potentially significant molecular player in the development of aggressive breast cancer.

The team's findings show that a protein called NEDD9 is critical in the formation of breast tumors induced by high levels of the cell-surface receptor HER2/neu in mice. HER2-driven breast cancer is known to be one the most aggressive forms of the disease.

Joy L. Little, Ph.D., a postdoctoral fellow in the laboratory of Erica A. Golemis, Ph.D., at Fox Chase Cancer Center, will present the findings at the 2010 annual meeting of the American Association for Cancer Research.

In mice engineered to overexpress the HER2/neu gene, Little and her colleagues found that 89% of mice with the Nedd9 gene developed tumors over an 18-month period. In comparison, only 29% of mice without the Nedd9 gene developed tumors. These findings indicate a novel role for NEDD9 in tumor initiation.

"There is a lot of research describing contributors to cancer formation, but it is always truly exciting when studies show that the loss or absence of something prevents cancer from occurring," says Little. "The fact that in the majority of our animals, HER2-driven tumors don't form without NEDD9 is new information we can use to view NEDD9 as a potential biomarker. If tumors show higher levels of NEDD9, it could be they are more aggressive."

Based on the data collected, researchers are now poised to delve deeper into discovering what about the biology of NEDD9 makes it crucial in the formation stages of HER2-driven tumors. Pharmacological targeting of NEDD9 could also be therapeutically relevant, Little notes.

Little is a second-time recipient of an AACR Scholar-in-Training Travel Award, given to young investigators. She is also the recipient of a National Cancer Institute postdoctoral award to further pursue study of NEDD9 biology.

Co-authors on the study include Fox Chase researchers Eugene Izumchenko, Ph.D. Mahendra K. Singh, Ph.D., Brian Egleston, Ph.D., Andres Klein-Szanto, M.D., and Erica A. Golemis, Ph.D.

Funding for this research comes from grants from the National Cancer Institute, National Institutes of Health, Israel Cancer Association, Stanley Abersur Research Foundation, Ben-Gurion University of the Negev, Pew Charitable Fund, and the Commonwealth of Pennsylvania.

Fox Chase Cancer Center is one of the leading cancer research and treatment centers in the United States. Founded in 1904 in Philadelphia as one of the nation's first cancer hospitals, Fox Chase was also among the first institutions to be designated a National Cancer Institute Comprehensive Cancer Center in 1974. Fox Chase researchers have won the highest awards in their fields, including two Nobel Prizes. Fox Chase physicians are also routinely recognized in national rankings, and the Center's nursing program has received the Magnet status for excellence three consecutive times. Today, Fox Chase conducts a broad array of nationally competitive basic, translational, and clinical research, with special programs in cancer prevention, detection, survivorship, and community outreach. For more information, visit Fox Chase's Web site at www.fccc.org or call 1-888-FOX CHASE or (1-888-369-2427).

Diana Quattrone | EurekAlert!
Further information:
http://www.fccc.edu

Further reports about: Cancer HER2-driven HER2/neu NEDD9 Nobel Prize Protein breast cancer

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>